Courtney Andersen studies the role of estrogen receptor-alpha in ovarian cancer.
Chris Barnes investigates the structural details by which transcription factor activity regulates RNA Polymerase II during the universal process of eukaryotic gene expression.
Soma Jobaggy studies nitrated fatty acid pharmacology and the antioxidant response in hypertensive end-organ damage.
Allison Nagle studies growth factor receptor signaling in breast cancer.
Journal Club Schedule

Pharmacology Journal Club

is held on selected Mondays during the Fall and Spring Terms in the Thomas E. Starzl Biomedical Tower, Conference Room 1395 beginning at 8:30 am.

 

Announcements may also be found on:

 The Department of Pharmacology & Chemical Biology Events Calendar

and on the electronic message board in the main hall on the 13th floor of BSTWR.

 

 





Previous Journal Clubs

12/11/2017- 10:00 AM : Chen-Shan Julia Woodcock

Therapeutic Potential of Electrophilic Nitro-oleic Acid for The Treatment of Triple Negative Breast Cancer


 


12/11/2017- 8:30 AM : Gregory Buchan
"Hepatic Acetyl CoA Links Adipose Tissue Inflammation to Hepatic Insulin Resistance and Type 2 Diabetes"

12/4/2017- 8:30 AM : Andrew Lamade
"Biochemical signaling by remote ischemic conditioning of the arm versus thigh: Is one raise of the cuff enough?"

11/27/2017- 8:30 AM : Lloyd Harvey
"Transmembrane helix hydrophobicity is an energetic barrier during the retrotranslocation of integral membrane ERAD substrates."

11/13/2017- 8:30 AM : Nicholas Todd
2-adrenergic receptor control of endosomal PTH receptor signaling via Gβγ"

11/6/2017- 8:30 AM : Braulio Bonilla
"MEF2C-MYOCD and Leiomodin1 Suppressionby miRNA-214 Promotes Smooth Muscle Cell Phenotype Switching in Pulmonary Arterial Hypertension"

10/30/2017- 8:30 AM : Alparsian Asan
"Selective Loss of Smaller Spines in Schizophrenia"

10/23/2017- 8:30 AM : Anastasia Gorelova
"TSP1–CD47 signaling is upregulated in clinical pulmonary hypertension and contributes to pulmonary arterial vasculopathy and dysfunction "

10/10/2017- 8:30 AM : Soma Jobbágy
"Organum Vasculosum of the Lamina Terminalis Detects NaCl to Elevate Sympathetic Nerve Activity and Blood Pressure"

10/2/2017- 8:30 AM : Ryan Staudt
"Pharmacologic Inhibition of MALT1 Protease by Phenothiazines as a Therapeutic Approach for the Treatment of Aggressive ABC-DLBCL"

9/25/2017- 8:30 AM : Atinuke "Oyin" Dosunmu-Ogunbi
"The Furan Fatty Acid Metabolite CMPF Is Elevated in Diabetes and Induces b Cell Dysfunction"

9/18/2017- 8:30 AM : Ravi Patel
“SOX2 promotes lineage plasticity and antiandrogen resistance in TP53- and RB1-deficient prostate cancer”

8/11/2017- 9:00 AM : Graduate Student Summer Seminar presented by Zachary Yochum and Eleanor Johnston

 "EMT transcription factor TWIST1 mediates resistance to EGFR inhibitors in EGFR-mutant non-small cell lung cancer”

Zachary Yochum

and

"Targeting the DNA Damage Response to improve NSCLC therapeutics"

Eleanor Johnston



8/4/2017- 9:00 AM : Graduate Student Summer Seminar presented by Greg Buchan and Soma Jobbágy

 "Evaluating the therapeutic potential of electrophilic fatty acid derivatives during severe influenza infection"

Greg Buchan

and

"Physiologic function of Nrf2 signaling in cardiovascular and renal systems"

Soma Jobbágy



7/21/2017- 9:00 AM : Graduate Student Summer Seminar presented by Rochell Fletcher and Song-My Hoang

 "Non-steroidal anti-Inflammatory drugs (NSAIDs) induce ER stress and have an immunomodulatory role in the suppression of colorectal tumorigenesis"

Rochell Fletcher

and

"Consequences of deregulated PAR metabolism for telomere maintenance by ALT"

Song-My Hoang



7/14/2017- 9:00 AM : Graduate Student Summer Seminar presented by Vera Procaccia and Nick Smith

 "EBP50/NHERF-1 regulates basal and TNFα-induced mitochondrial dynamics in vascular smooth muscle cells"

Vera Procaccia

and

"Evidence for RET oncogene activation in metastatic breast cancers"

Nick Smith



7/7/2017- 9:00 AM : Graduate Student Summer Seminar presented by Alison Nagle and Zheqi Li

 "Developing an invasive lobular breast cancer ex vivo culture method for high-throughput drug screening”

Alison Nagle

and

“ESR1 mutations confer novel metastatic functions in genome-edited breast cancer cell models”

Zheqi Li



6/30/2017- 9:00 AM : Graduate Student Summer Seminar presented by Andrew Lamade and Stephanie Mutchler

 “Targeting mitochondrial PARP1 in neuronal ischemia-reperfusion injury”

Andrew Lamade

and

"Vascular ENaC in the control of vascular reactivity and blood pressure"

Stephanie Mutchler



6/16/2017- 9:00 AM : Graduate Student Summer Seminar presented by Josh Lorenz-Guertin and Ravi Patel

"Diazepam Induces Bidirectional Modulation of the GABA type A Receptor”

Josh Lorenz-Guertin

and

"Targeting SRC-family kinases to combat acquired inhibitor resistance in FLT3-ITD+ AML"

Ravi Patel



6/9/2017- 9:00 AM : Graduate Student Summer Seminar presented by Alparslan Asan and Ryan Staudt

 "RAD51 inhibition by OA-NO2 is a potential co-treatment for triple negative breast cancer”

Alparslan Asan

and

"Exploring the Mechanisms by which Small Molecule Nef Inhibitors Suppress HIV-1 Infectivity"

Ryan Staudt


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STUDENT NEWS


UPCOMING EVENTS
1/11/2018 12:00 PM Pharmacology & Chemical Biology Seminar Series
Kara Bernstein, Ph.D.


1/18/2018 12:00 PM Pharmacology & Chemical Biology Seminar Series
Donald DeFranco, Ph.D.


1/25/2018 12:00 PM Pharmacology & Chemical Biology Seminar Series
Edwin Levitan, Ph.D.


Pharmacology and Chemical Biology Event Calendar

Program Achievements

Molecular Pharmacology Graduate Program Ranked #2 in National Research Council Rankings

Outcomes:  Time to disseration, last five graduating clasess:  4.5 years, Completion Rate: 84.8%

Ranked #12 in National of Institute of Health funding of departments of Pharmacology

Ranked in the top 15 in funding for twenty two consecutive years




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