Courtney Andersen studies the role of estrogen receptor-alpha in ovarian cancer.
Chris Barnes investigates the structural details by which transcription factor activity regulates RNA Polymerase II during the universal process of eukaryotic gene expression.
Soma Jobaggy studies nitrated fatty acid pharmacology and the antioxidant response in hypertensive end-organ damage.
Allison Nagle studies growth factor receptor signaling in breast cancer.
Angela M. Gronenborn, PhD
Rosalind Franklin Professor and Chair, Structural Biology.
1050 BST 3
3501 Fifth Avenue, PA 15260

Phone: 412-648-9959


BS (Chemistry, Physics), University of Cologne, 1972.
MS (Chemistry), University of Cologne, 1975.
PhD (Organic Chemistry) University of Cologne, 1978.

Research Areas
Structural Pharmacology
Signal Transduction
Photo of Angela M. Gronenborn, PhD

Our research combines nuclear magnetic resonance (NMR) spectroscopy with Biophysics, Biochemistry, and Chemistry to investigate cellular processes at the molecular and atomic levels in relation to human disease. We presently focus on two areas in biology: Gene Regulation and HIV pathogenesis. In order to understand how biological macromolecules work and intervene in a rational manner with respect to activity and function, detailed knowledge of their architecture and dynamic features is required. Evaluation of the major determinants for stability and conformational specificity of normal and disease-causing forms of these molecules, will allow us to unravel the complex processes associated with disease.


Our group has developed new NMR methods for determining three-dimensional structures of biological macromolecules and applied these to challenging system. Key contributions include the development of restrained molecular dynamics/simulated annealing algorithms and multidimensional, heteronuclear spectroscopy, which allowed the extension of conventional NMR methods to higher molecular weight systems. The Gronenborn group has solved solution structures of a large number of medically and biologically important proteins, including cytokines and chemokines, transcription factors and their complexes and various HIV and AIDS related proteins. Work is also carried out on protein folding and design using the model protein GB1.


3/28/2019 10:45 AM Molecular Pharmacology Journal Club
Victoria Veroli

3/28/2019 12:00 PM Pharmacology & Chemical Biology Seminar Series
Da Yang, MD, PhD

4/3/2019 1:00 PM Doctoral Dissertation Defense
Stephanie Mutchler

Pharmacology and Chemical Biology Event Calendar

Program Achievements

Molecular Pharmacology Graduate Program Ranked #2 in National Research Council Rankings

Outcomes:  Time to disseration, last five graduating clasess:  4.5 years, Completion Rate: 84.8%

Ranked #12 in National of Institute of Health funding of departments of Pharmacology

Ranked in the top 15 in funding for twenty two consecutive years

Back to Top