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  Pharmacology Department at the University of Pittsburgh  
Pharmacology
Pharmacology
Pharmacology

Doctoral Dissertations

Caveolin-1 mediated p53 activation in stress induced premature senescence and its antagonistic pleiotropic implications in cancer
2009
Advisor: Ferruccio Galbiati PhD
Student: Janine N. Bartholomew
 
Elucidating the role of Cdc25A in hypoxia-mediated cell cycle arrest
2009
Advisor: John S. Lazo PhD
Student: Pierre Queiroz-Oliveira
 
Epithelial Reparative Capacity Regulates Extracellular Matrix Dynamics and Innate Immunity
2009
Advisor: Barry R. Stripp PhD
Student: Joshua Snyder
 
Expression and Function of Urothelial Nicotinic Acetylcholine Receptors
2009
Advisor: Lori A. Birder PhD
Student: Jonathan M. Beckel
 
Investigating the SRC kinase HCK functions in Chronic Myelogenous Leukemia using chemical genetics methods
2009
Advisor: Thomas Smithgall PhD
Student: Theodora Pene-Dumitrescu
 
Investigation of the mechanisms and therapeutic implications of crosstalk between G-protein-coupled receptors and the Epidermal Growth Factor Receptor in HNSCC
2009
Advisor: Jennifer Grandis MD
Student: Neil Bhola
 
Cellular and Biochemical Regulation of Cdc25A Phosphatase by Nitrosative Stress
2008
Advisor: John S. Lazo PhD
Student: Robert Tomko
 
Differential Localization of Hic-5 and Paxillin in the Brain of Alzheimer's Disease Subjects
2008
Advisor: Donald DeFranco PhD
Student: John Caltagarone
 
Extrasynaptic GABA Type A Receptors in the Mechanism of Action of Ethanol
2008
Advisor: Gregg E. Homanics PhD
Student: Dev Chandra
 
Identification of Novel Potential Cancer Therapies by Synthetic Lethal Screening
2008
Advisor: John S. Lazo PhD
Student: Peter R. McDonald
 
The Role of SMAC in NSAID-induced Apoptosis
2008
Advisor: Lin Zhang PhD
Student: Aleksandr Bank
 
Elucidating the Role of a i-Contacting Gaba (A) Receptors in Ethanol Action
2007
Advisor: Gregg E. Homanics PhD
Student: David F. Werner
 
Human REV3L Expression and Protein Interaction Studies
2007
Student: Gregory N. Gan
 
Induction of CD25B Following DNA Damage: Implications for Cell Cycle Resumption and Tumorgenesis
2007
Advisor: John S. Lazo PhD
Student: Pallavi Bansal
 
Regulatory Networks of PXR, Car and LXR in Cholesterol and Bile Acid Metabolism
2007
Advisor: Wen Xie PhD
Student: Hirdesh Uppal
 
T1di Mediates Agrin and Muscle Specific Kinase Signaling at the Neuromuscular Junction
2007
Advisor: Zuo-Zhong Wang, PhD
Student: Jenny J. Linnoila
 
Mitochondrial DNA in neurons and its modulation by neurotoxins
2006
Advisor: Ian Reynolds, PhD
Student: Maria S. Santos
 
Modulation of Angiotensin II-Induced Renal Vascular Presponses by PP-Fold Peptides
2006
Advisor: Edwin Jackson PhD
Student: John H. Dubinion Jr.
 
Screening Assay for Selective Estrogen Receptor Modulators
2006
Advisor: Mark Nichols Ph.D.
Student: Elena Sirbu
 
The Renal Bumetaride-Sensitive Na-K-2Cl Cotransporter BSC-1/NKCO2 in Essential Hypertension and Its Regulation by Norepinephrine
2006
Advisor: Edwin Jackson PhD
Student: Prajakta Sonalker
 
Characterization of Nuclear Matrix Alterations Involved in Bladder Cancer Progression
2005
Advisor: Robert Getzenberg, PhD
Student: Julie Myers-Irvin
 
Epidermal Growth Factor Receptor (EGFR) Activation by Gastrin Releasing Peptide (GRP) in Head and Neck Cancer: Mechanisms and Clinical Implications
2005
Advisor: Jennifer Grandis MD
Student: Qing Zhang
 
Interactions between Zinc and Mitochondria in Neuronal Injury
2005
Advisor: Ian J. Reynolds, Phd
Student: Latha Malaiyandi
 
Lipid Binding and the Sceffolding function of the Kinase Suppressor of Ras
2005
Advisor: Guillermo Romero PhD
Student: Catherine Kraft
 
Meditation of Chemotherapy-Induced Apoptosis by the Lysosomal Protease Cathespin D
2005
Advisor: Daniel Johnson PhD
Student: Lori Emert-Sedlak
 
Mitochondrial Trafficking in Healthy and Injured Neurons
2005
Advisor: Ian J. Reynolds, PhD
Student: Diane T.W. Chang
 
Evaluation of the Physiological Functions of Bleomycin Hydrolase in the Murine CNS
2004
Advisor: John S. Lazo PhD
Student: Susana Montoya
 
Regulation of CDC25A in Human Tumor Cells by Cyclin-Dependent Kinase 2
2004
Advisor: John S. Lazo PhD
Student: Alex Ducruet
 
Mechanisms of Polyglutamine Expanded Huntingtin Induced Toxicity
2003
Advisor: Donald DeFranco PhD
Student: Haibing Jiang
 
An Investigation of the Neurotoxic Properties of Zinc
2002
Advisor: Ian J. Reynolds, PhD
Student: Kirk Dineley
 
Angiotensin II Signaling to Phospholipase D in a Model of Genetic Hypertension
2002
Student: Brad Andresen
 
Protective Role of the 2-Hydroxyesteradiol Methylation Pathway in the Cardiovascular and Renal Systems: Interaction with Catecholamines
2002
Advisor: Edwin Jackson PhD
Student: Lefteris Zacharia
 
Vitamin D in Cancer Therapy: Mechanistic Studies and Novel Combinations
2002
Advisor: Candace S. Johnson, PhD
Student: Ron Bernardi
 
Enhancement of Neuropeptide Release by Increasing the Mobility of Secretory Granuler
2001
Advisor: Edwin Levitan PhD
Student: Yuen-Keng Ng
 
Overcoming the Inflammatory Toxicity in Cationic Lipid Vector Mediated System Gene Delivery
2001
Advisor: Leaf Huang, PhD
Student: Yadi Tan
 
Regulation of KU4.3 and KV1.5KV Potassium Channel Expression in Cardiac Mycytes and GH3 Pituitary Cells
2001
Advisor: Edwin Levitan PhD
Student: Ting-Ting Zhang
 
Antitumor Activity of the LPD Lipopolyplex Prepared with Immunostimulatory CpG DNA
2000
Advisor: Leaf Huang, PhD
Student: Mark Whitmore
 
The Role of Mitochondria in Glutamate-Induced Neuronal Injury
2000
Advisor: Ian J. Reynolds, PhD
Student: Joelle Scanlon
 
The Role of Phospholipase D in the Regulation of the Mitogen-Activated Protein Kinase Cascade
2000
Student: Mark Rizzo
 
Development of an Improved Cytoplasmic Expression System for Gene Therapy
1999
Advisor: James Perel MD
Student: Marni Brisson
 
Relationship Between the Concentration of Intracellular Divalent Cations and Excitotoxicity
1999
Advisor: Ian J. Reynolds, PhD
Student: Chialin Cheng
 
Asymmetric Synthesis, Pharmacology, and Pharmacokinetics of the Three Enantiomers of methyphenidate and their Para-Substituted Analogues
1997
Advisor: James Perel MD
Student: Dung Luong Thai
 
Targeting Ras Prenylation in Anti-Cancer Therapy
1997
Advisor: Said M. Sebti, PhD
Student: Edwina Lerner
 
A Complex Interrelationship between Cyctoplasmic Calcium Homeostasis and Mitochondrial Physiology in Cultured Forebrain Neurons
1996
Advisor: Ian J. Reynolds, PhD
Student: James White, III
 
Aspects of B Cell Differentiation and Apoptosis
1996
Advisor: Christine Milcarek, PhD,Justus Cohen, PhD, Ronald Goldfarb, PhD
Student: Lina Khalil Charles Rudolf Sovan
 
Dopamine and Glutamate Interactions in Cultured Neurons
1996
Advisor: Ian J. Reynolds, PhD
Student: Karl Rene Hoyt
 
Glutamate-Induced Changes in Intracellular Calcium and Magnesium in Rat Forebrain Neurons in Bitro: Relationship to Excitotoxicity
1995
Advisor: Ian J. Reynolds, PhD
Student: Sunita Rajdev
 
Protein Kinase Ce Modulation of Higher Order Chromatin Cleavage in Apoptotic Androgen-Independent Human Prostatic Carcinoma Cells
1995
Advisor: John S. Lazo PhD
Student: James Michael Rusnak
 
Clinical Variability in Inerited Sodium Chennelopathies: Studies of heterogeneity at the Gene and Gene Expression Levels
1994
Advisor: Eric P. Hoffman, PhD
Student: Jianhua Zhou
 
Role of Mesage Turnover in Influencing the Abundance of B Cell mRNAs During Ontogeny
1992
Advisor: Christine Milcarek, PhD
Student: Susan C. Croll
 
The Effects of Methylphenidate and amphetamine on Synaptosomal Uptake, Prolactin, and Linear Growth in Rat Pups-A Model of Pharmacological Effects
1984
Advisor: James Perel MD
Student: Ann Marie Mackway Wells
 
Ethylcholine Aziridinum: A New Cholinergic Specific Presynaptic Toxin
1983
Advisor: Israel Hanin, PhD
Student: Charles R. Mantione
 
Lactate and Pyruvate Levels in the Mouse Oviduct
1981
Advisor: Robert H. Connamacher, PhD
Student: Gary Leopold Nieder
 
Autonomic Control of the Colon of the Cat
1977
Advisor: William C. de Groat PhD
Student: Jacob Krier
 
Isolation, Partial Characterization, and Distribution of Rat Kidney NAD+-Dependent/5-Hydroxyprostaglandin Dehydrogenase
1977
Advisor: Clinton N. Corder, PhD
Student: Jackson Thomas Wright Jr.
 
Studies on the Sodium-Potassium Dependednt Adenosine Triphosphate from Human Renal Tissue
1977
Advisor: Clinton N. Corder, PhD
Student: John Mark Braughler
 
An Investigation of the Cholinergic System of the Isolated Electroplaque from Electrophorus Electrices
1972
Advisor: Henry B. Higman, PhD
Student: William H. Thies
 
Stimulatory Effects of Acetylcholine on Rate of the Intact Atropinized Cat Heart
1967
Advisor: Paul L. McLain, PhD
Student: Dale Bernard Evans
 
 
The Effects of Leisons of the Posterior Funiculi of Macaca Mulatta
Student: Richard J. Schneider
 
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