Necroptosis is a programed, caspase-independent cell death that is morphologically similar to necrosis.  Although recent studies have reported that necroptotic pathway may be involved in tumor development, it is not clear if tumor cells undergo necroptosis during tumor development and if so, what role necroptosis of tumor cells plays in tumorigenesis. Tumor necrosis is often seen in aggressive solid cancers with a poor prognosis. The underlying mechanism of tumor necrosis and its role in tumor development and metastasis is largely unknown and is an under-studied research area because of the lack of knowledge about the mechanism of tumor necrosis. We recently demonstrated that tumor necroptosis is responsible for tumor necrosis and promotes the late tumor growth and metastasis through regulating several aspects of tumor microenvironment, such as tumor immunity.