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Professor of Anesthesiology/Critical Care Medicine
2048 Biomedical Science Tower 3
3501 5th Ave, Pittsburgh, PA 15260
Phone: 412-648-9922
Email: xu2@pitt.edu
Fax: 412-648-9009
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Links for this Faculty Member
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Research Description:
Dr. Xu and his research group are interested in (1) rational design of new therapeutic strategies for treatment of brain injury during and after cardiac arrest, (2) the molecular mechanisms underlying the actions of nonspecific drugs on the ligand-gated neuronal receptors in their membrane environment, and (3) functional mapping of neural activities in drug-induced unconscious state. In the first project, research activities are particularly directed at evaluating therapeutic potentials of umbilical cord matrix stem cells. The second project involves the 3-D structure determination of functional segments of human glycine receptor. The current focus of the third project is on differentiating receiving and perceiving external stimulations in the visual and olfactory systems.
Education:
B.S. (Physics), University of Science and Technology of China, 1982.
Ph.D. (Chemistry), State University of New York at Stony Brook, 1990.
Postdoctoral Fellow (Pharmaceutical Chemistry and Anesthesiology),University of California at San Francisco, 1990-92.
Important Publications:
- Xu Y, SM Liachenko, P Tang and PH Chan. Faster recovery of cerebral perfusion in SOD1-overexpressed rats after cardiac arrest and resuscitation. Stroke 40:2512-2518, 2009
- Canlas C. D Ma, L Li, P Tang and Y Xu. Structural refinement of transmembrane proteins in aligned low-q bicelles using high-resolution magic angle spinning for residual dipolar coupling measurements. J Am Chem Soc 130:13294-13300, 2008
- Hirko A, R Dallasen, S Jomura and Y Xu. Modulation of inflammatory responses after global ischemia by transplanted umbilical-cord matrix stem cells. Stem Cells 26:2893-2901, 2008
- Ma D, NR Brandon, T Cui, V Bondarenko, CG Canlas, JS Johansson, P Tang and Y Xu. Four-alpha-helix bundle with designed anesthetic binding pockets I: Structural and dynamical analyses. Biophys J 94:4454-4463, 2008
- Ma D, T Tillman, P Tang, E Meirovitch, R Eckenoff, A Carnini and Y Xu. NMR studies of a channel protein without membranes: Structure and dynamics of water-solubilized KcsA. Proc Natl Acad Sci USA 105:16537-16542, 2008
- Jomura S, M Uy, K Mitchell, R Dallasen, C Bode and Y Xu. Potential treatment of cerebral global ischemia with umbilical cord matrix stem cells. Stem Cells 25:98-106, 2007
- Tang P and Y Xu. Large-scale molecular dynamics simulations of general anesthetic effects on ion channel in fully hydrated membrane: Implication of molecular mechanisms of general anesthesia. Proc Natl Acad Sci USA 99: 16035-16040, 2002
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