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Professor of Pharmaceutical Sciences and Chemistry Director, Proteomics Core Lab
10017 BST3
3501 Fifth Avenue,, PA 15260
Phone: 412-648-9706
Email: bday@pitt.edu
Fax: 412.624.1850
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Links for this Faculty Member
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Research Description:
Dr. Day's lab is interested in the discovery and development of drugs to treat solid tumors. The lab uses computational chemistry, synthetic medicinal chemistry, biochemical methods, cell biology, molecular techniques, radio- and stable isotope labeling syntheses, mass spectrometry and animal models to discover new agents then study their mechanisms of action. Projects include: design and synthesis of truncated versions of the potent microtubule stabilizer discodermolide; high-throughput biochemical and cell based screening of parallel and combinatorial libraries of anti-tubulin and anti-dynein agents; characterization of changes in signal transduction cascades by synthetic agents; parallel solid- and solution-phase synthesis of 1,1-dichloro-2,2,3-triarylcyclopropanes and 2,3-diarylcyclopropyl phenyl ketones as estrogen receptor modulators; and quantitative structure-activity relationship analyses of synthetic libraries. The lab also collaborates extensively both in and outside the university in the areas of computational design/discovery, synthesis, redox biochemistry and both small molecule and macromolecule mass spectrometry (proteomics).
Education:
B.S. (Chemistry & Biology), Oklahoma City University, 1982
Ph.D. (Medicinal Chemistry), University of Oklahoma, 1988
Postdoctoral Fellow, Massachusetts Institute of Technology, 1988-91
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