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  Pharmacology Department at the University of Pittsburgh  
Pharmacology
Pharmacology
Pharmacology

Bruce A. Freeman Ph.D.

 

Professor and Chair

W1346 Thomas E. Starzl Biomedical Science Tower
200 Lothrop Street, Pittsburgh, PA 15261

Phone: 412-648-9319
Email: freerad@pitt.edu
Fax: 412-648-2229

Links for this Faculty Member

 

 
 

Research Description:

Education:

B.S. (Biochemistry), University of California, Riverside, 1974.
Ph.D. (Biochemistry), University of California, Riverside, 1978.

Important Publications:

  • Iles KE, MM Wright, MP Cole, NE Welty, LB Ware, MA Matthay, FJ Schopfer, PRS Baker, A Agarwal and BA Freeman.  Fatty acid transduction of nitric oxide signaling:  Nitrolinoleic acid mediates protective effects through regulation of the ERK pathway.  Free Radical Biology & Medicine 46:866-875, 2009
  • Rudolph V, FJ Schopfer NKH Khoo, TK Rudolph, MP Cole, SR Woodcock, G Bonacci, AL Groeger, F Golin-Bisello, C-S Chen, PRS Baker and BA Freeman.  Nitro-fatty acid metabolome:  Saturation, desaturation, β-oxidation, and protein adduction.  J Biol Chem 284:1461-1473, 2009
  • Freeman BA, PRS Baker, FJ Schopfer, SR Woodcock, A Napolitano and M d’Ischia . Nitro-fatty acid formation and signaling.  J Biol Chem 283:15515-15519, 2008
  • Batthyany C, FJ Schopfer, PR Baker, R Duran, LM Baker, Y Huang, C Cervenansky, BP Branchaud and BA Freeman. Reversible post-translational modification of proteins by nitrated fatty acids in vivo. J Biol Chem 281(29):20450-20463, 2006
  • Eiserich JP, S Baldus, M-L Brennan, W Ma, C Zhang, A Tousson, L Castro, AJ Lusis, CR White and BA Freeman. Myeloperoxidase: A leukocyte-derived vascular •NO oxidase. Science 296:2391-2394, 2002
  • Radi R, JS Beckman and BA Freeman.  Peroxynitrite oxidation of sulfhydryls: The cytotoxic potential of endothelial-derived superoxide and nitric oxide.  J Biol Chem 266:4244-4250, 1991
  • Beckman JS, TW Beckman, J Chen, PA Marshall and BA Freeman. Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci 87:1620-1624, 1990
 

 

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