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Research Description:
Dr. de Groat is interested in the autonomic nervous system and the neural regulation of pelvic visceral functions. Current studies focus on the reflex control of the urogenital tract and the mechanisms underlying transmission at central and peripheral autonomic synapses. These experiments are designed to examine (1) the neurotransmitters in the reflex pathways, (2) neuroplasticity during postnatal development or following neural injury, (3) the neural pathways responsible for the detection of visceral pain, and (4) the actions of drugs used to treat urogenital dysfunction. Experiments are conducted on a variety of preparations ranging from intact animals to isolated tissues, like spinal cord slices and dissociated neurons.
Education:
B.S. (Pharmacy), Philadelphia College of Pharmacy and Science, 1960.
M.S. (Pharmacology), Philadelphia College of Pharmacy and Science, 1962.
Ph.D. (Pharmacology), University of Pennsylvania Medical School, 1965.
Postdoctoral Fellow, University of Pennsylvania Medical School, 1965-1966.
Postdoctoral Fellow, Australian National University, Dept. of Physiology, 1966-1968.
Important Publications:
- Cheng CL and WC de Groat. The role of 5HT1A receptors in the control of lower urinary tract functions in anesthetized rats. Am J Physiol Renal Physiol 289:F771-F778, 2010
- Hezel MP, WC de Groat and F Galbiati. Caveolin-3 promotes nicotinic acetylcholine receptor clustering and regulates neuromuscular junction activity. Molecular Biology of the Cell 21:302-310, 2010
- Kullmann A, LA Birder, M Shah and WC de Groat. Functional TRP and ASIC-like channels in cultured urothelial cells from the rat. American Journal of Physiology: Renal Physiology 296:F892-F901, 2009
- Sculptoreanu A, D Artim and WC de Groat. Neurokinins inhibit low threshold inactivating K+ currents in capsaicin responsive DRG neurons. Experimental Neurology 219:562-573, 2009
- Tai C, J Wang, JR Roppolo and WC de Groat. Relationship between temperature and stimulation frequency in conduction block of amphibian myelinated axons. Journal of Computational Neuroscience 26:331-338, 2009
- Tai C-F, JR Roppolo and WC de Groat. Brain switch for reflex micturition control detected by fMRI in rats. Journal of Neurophysiology 102:2719-2730, 2009
- Ng GA, R Mantravadi, WA Walker, WG Ortin, B-R Choi, WC de Groat and G Salama. Sympathetic nerve stimulation produces spatial heterogeneities of action potential restitution. Heart Rhythm 6:696-706, 2009
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