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Research Description:
Dr. de Groat is interested in the autonomic nervous system and the neural regulation of pelvic visceral functions. Current studies focus on the reflex control of the urogenital tract and the mechanisms underlying transmission at central and peripheral autonomic synapses. These experiments are designed to examine (1) the neurotransmitters in the reflex pathways, (2) neuroplasticity during postnatal development or following neural injury, (3) the neural pathways responsible for the detection of visceral pain, and (4) the actions of drugs used to treat urogenital dysfunction. Experiments are conducted on a variety of preparations ranging from intact animals to isolated tissues, like spinal cord slices and dissociated neurons.
Education:
B.S. (Pharmacy), Philadelphia College of Pharmacy and Science, 1960.
M.S. (Pharmacology), Philadelphia College of Pharmacy and Science, 1962.
Ph.D. (Pharmacology), University of Pennsylvania Medical School, 1965.
Postdoctoral Fellow, University of Pennsylvania Medical School, 1965-1966.
Postdoctoral Fellow, Australian National University, Dept. of Physiology, 1966-1968.
Important Publications:
- Furuta A, K Asano, S Egawa, WC de Groat, MB Chancellor and N Yoshimura. Role of alpha 2-adrenoceptors and glutamate mechanisms in the external urethral sphincter continence reflex in rats. Journal of Urology 181:1467-1473, 2009
- Kullmann A, LA Birder, M Shah and WC de Groat. Functional TRP and ASIC-like channels in cultured urothelial cells from the rat. American Journal of Physiology: Renal Physiology 296:F892-F901, 2009
- Ng GA, R Mantravadi, WA Walker, WG Ortin, B-R Choi, WC de Groat and G Salama. Sympathetic nerve stimulation produces spatial heterogeneities of action potential restitution. Heart Rhythm 6:696-706, 2009
- Fowler CJ, D Griffiths and WC de Groat. The neural control of micturition. Nature Reviews Neuroscience 9:453-466, 2008
- Kullmann F, D Artim, L Birder and WC de Groat. Activation of muscarinic receptors in rat bladder sensory pathways alters reflex bladder activity. Journal of Neuroscience 28:1977-1987, 2008
- Sculptoreanu A, FA Kullman and WC de Groat. Neurokinin 2 receptor mediated activation of protein kinase C modulates capsaicin responses in DRG neurons from adult rats. European Journal of Neuroscience 27:3171-3178, 2008
- Srinivasan R, D Wolfe, J Goss, S Watkins, WC de Groat, A Sculptoreanu and JC Glorioso. PKCε contributes to basal and sensitizing response of Trpv1 to capsaicin in dorsal root ganglion neurons. European Journal of Neuroscience 28:1241-1254, 2008
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