Dr. Wang researches parathyroid hormone receptor trafficking, interaction with the adapter protein EBP50/ NHERF1 and other proteins, and their effects on the signaling in kidney and bone cells. The goal of these studies will contribute to our understanding of mineral ion homeostasis under normal conditions, as well as the pathogenesis of diseases that are related to disordered calcium and phosphorus balance in renal failure, hyperparathyroidism, or osteoporosis. The results will provide insights into developing drugs for selective therapeutic applications.

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Important Publications

Alonso VA, JA Ardura, B Wang, WB Sneddon and PA Friedman.  A naturally occurring isoform inhibits parathyroid hormone receptor trafficking and signaling.  J Bone Miner Res 26:143-145, 2011.

Wang B, JA Ardura, G Romero, Y Yang, RA Hall and PA Friedman.  Na/H exchanger regulatory factors control PTH receptor signaling by facilitating differential activation of Ga protein subunits.  J Biol Chem 285:26976-26986, 2010.

Klenk C, T Vetter, A Zurn, JP Vilardaga, PA Friedman, B Wang and MJ Lohse.  Formation of a ternary complex between NHERF1, {beta}-arrestin, and parathyroid hormone receptor.  J Biol Chem 285:30355-30362, 2010.

Wang B, Y Yang, AB Abou-Samra and PA Friedman.  NHERF1 regulates parathyroid hormone receptor desensitization:  Interference with ß-arrestin binding.  Mol Pharm 75:1189-1197, 2009.

Wang B and Y Yang.  Generation of human PTH1R construct with Flag epitope located internally:  Comparison of two-fragment assembly by using PCR overlap extension or ligase.  J Biomol Tech 20:195-200, 2009.

Ferrandon S, TN Feinstein, M Castro, B Wang, R Bouley, JT Potts, TJ Gardella and JP Vilardaga.  Sustained cyclic AMP producton by parathyroid hormone receptor endocytosis.  Nat Chem Biol 5:734-742, 2009.

Wang B, Y Yang and PA Friedman. NHERF1, a novel AKT-associating protein, regulates ERK signaling through a B-Raf mediated pathway. Mol Biol Cell 19:1637-1645, 2008.

Wang B, A Bisello, Y Yang, GG Gomero and PA Friedman . NHERF1 regulates parathyroid hormone receptor membrane retention without affecting recycling. J Biol Chem 282: 26214-26222, 2007.