Department of Pharmacology & Chemical Biology at the University of Pittsburgh
Eric Kelley, PhD
Assistant Professor, Anesthesiology
W1357 Thomas E. Starzl Biomedical Science Tower 200 Lothrop Street
Pittsburgh, PA 15261

Email:
ekelley@pitt.edu
Phone: 412-648-9683

Fax: 412-648-9688


Education

BS (Microbiology), University of Iowa, 1991.
MS (Radiation Biology), University of Iowa, 2000.
PhD (Free Radical), University of Iowa, 2002.


Dr. Kelley’s research centers on the role of oxidative stress in vasculature inflammation with a primary focus on the modulation of endothelial homeostasis by xanthine oxidase (XO)-derived ROS. Such ROS production, when it occurs in the vascular compartment, can impact vessel function by modulation of redox-dependent cell signaling reactions or by the reduction of •NO bioavailability due to its direct reaction with superoxide. An expanding number of animal models and clinical studies affirm a key role for XO in tissue pathology where inhibition of XO activity attenuates symptoms of vascular disease. However, recently reported studies demonstrate under severe hypoxia, XO may function as a nitrite reductase and thus assume a protective role by serving as a source of vasoactive nitric oxide (NO). Therefore, in order to develop novel treatment strategies, Dr. Kelley’s efforts are globally targeted to develop a more comprehensive understanding of XO-derived ROS/RNS in vascular inflammatory processes.




Important Publications
Kelley EE, NK Khoo, NJ Hundley, UZ Malik, BA Freeman and MM Tarpey. Hydrogen peroxide is the major oxidant product of xanthine oxidase. Free Rad Biol Med 48:493-498, 2010.

Kelley EE, CI Batthyany, NJ Hundley, SR Woodcock, G Bonacci, JM Del Rio, FJ Schopfer, JR Lancaster, BA Freeman and MM Tarpey.  Nitro-oleic acid, a novel and irreversible inhibitor of xanthine oxidoreductase. J Biol Chem 283:36176-36184, 2008.

Lang JD, X Teng, PH Chumley, J Crawford, TS Isbell, BK Chacko, Y Liu, N Jhala, R Crowe, AB Smith, RC Cross, L Frenette, EE Kelley, DW Wilhite, CR Hall, GP Page, JS Bynon, DE Eckhoff and RP Patel.  Preemptive administration of inhaled nitric oxide accelerates restoration of liver function in adults following orthotopic liver transplantation. J Clin Invest 117:2583-2591, 2007.
Kelley EE, T Hock, NKH Khoo, PC Powell, G Giles, GR Richardson, A Agarwal, J Lancaster and MM Tarpey.  Moderate hypoxia induces xanthine oxidoreductase activity in arterial endothelial cells. Free Rad Biol Med 40:952-959, 2006.
Kelley EE, A Trostchansky, H Rubbo, BA Freeman, R Radi and Tarpey, MM. Binding of xanthine oxidase to glycosaminoglycans limits inhibition by oxypurinol. J Biol Chem 279(36):37231-37234, 2004.

Rodriguez AI, A Gangopadhyay, EE Kelley, PJ Pagano, BS Zuckerbraun and PM Bauer. HO-1 and CO decrease platelet-derived growth factor-induced vascular smooth muscle cell migration via inhibition of Nox1. Arterioscler Thromb Vas Biol 30(1):98-104, 2010.





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