Department of Pharmacology & Chemical Biology at the University of Pittsburgh
John S. Lazo, PhD
Professor Emeritus

Email:
lazo@pitt.edu

Education
BA (Chemistry), Johns Hopkins University, 1971.
PhD (Pharmacology), University of Michigan, 1976.
Postdoctoral Fellow, Yale University School of Medicine, 1976-1978.


Research Areas
Protein Kinases & Phosphatases
Photo of John S. Lazo, PhD

The Lazo laboratory is primarily focusing on studying how enzymes that remove high energy phosphates from proteins controlling cell division, migration and survival using both molecular biological and pharmacological approaches. Other major themes include determining the mechanism of action of new anticancer agents and the development of both high through and high content screens of small molecule chemical libraries.


Figure 1





Important Publications
Sharlow ER, TA Lyda, HC Dodson, G Mustata, MT Morris, SS Leimgruber, K Lee, Y Kashiwada, D Close, JS Lazo and JC Morris.  A target-based high throughput screen yields Trypanosoma brucei hexokinase small molecule inhibitors with antiparasitic activity.  PLoS Neglected Tropical Diseases 4:e659, 2010.
Xu F, Y Rbaibi, K Kiselyov, JS Lazo, P Wipf and WS Saudners.  Induction of mitotic slippage by the microtubule inhibitor, disorazole C1.  BMC Chemical Biology 10:1, 2010.
Guiguemde W, A Shelet, D Bouck,S Duffy, G Crowther, P Davis, D Smithson, M Connelly, J Clark, F Zhu, M Jimenez-Diaz, M Martinez, E Wilson, A Tripathi, J Gut, E Sharlow, I Bathurst, F El Mazouni, J Fowble, I Forquer, P McGinley, S Castro, I Angulo-Barturen, S Ferrer, P Rosenthal, J DeRisi, D Sullivan, J Lazo, D Roos, M Riscoe, M Phillips, P Rathod, W Van Voorhis, V Avery and RK Guy.  Chemical genetics of Plasmodium falciparum.  Nature 465:311-315, 2010.
Thaker NG, F Zhang, PR McDonald, TY Shun, MD Lewen, IF Pollack and JS Lazo.  Identification of survival genes in human glioblastoma cells using siRNA screening.  Mol Pharmacol 76:1246-1255, 2009.
Sharlow ER, D Close, T Shun, S Leimgruber, R Reed, G Mustata, P Wipf, J Johnson, M O'Neil, M Grögl, AJ Magill and JS Lazo.  Identification of potent chemotypes targeting Leishmania major using a high-throughput, low-stringency, computationally enhanced, small molecule screen.  PLoS Neg Tropic Dis 3:e540, 2009.
Queiroz de Oliveira PE, L Zhang, Z Wang and JS Lazo.  Hypoxia-mediated regulation of Cdc25A phosphatase by p21 and miR-21.  Cell Cycle 8:3157-3164, 2009.
Molina G, A Vogt, A Bakan, W Dai, Queiroz de Oliveira P, T Smithgall, I Bahar, JS Lazo, BW Day and MI Tsang.  An allosteric inhibitor of Dusp6, identified by a transgenic zebrafish chemical screen, expands cardiac progenitors and heart size.  Nature Chem Biol 5:680-687, 2009.
Jainfei J, PR McDonald, TM Dixon, DA Franicola, X Zhang, S Nie, LD Epperly, VE Kagan, JS Lazo, MW Epperly and JS Greenberger.  Synthetic protection siRNA screen reveals glyburide as a novel radioprotector.  Radiation Res 172:414-422, 2009.




Back to Top