Normal metabolic and abnormal pathological roles of free radicals and reactive oxygen species serve as the focus of Dr. Kagan’s laboratory. Dr. Kagan is interested in both (i) the mechanisms involved in the enhance radical generation by physical and chemical factors (e.g. UV-irradition, transition and heavy metals, carcinogens, tumor necrosis factor, among others) and pathological conditions (e.g. ischemia/reoxigenation of the heart and brain), and (ii) the effects of these factors on endogenous antioxidants.
Specifically, three major research directions currently in Dr. Kagan’s laboratory are 1) Role of phenoxyl radicals in cytotoxicity of phenolic compounds. Strategies are being developed to enhance antitumor activity by modulating free radical metabolism of cytotoxic drugs (e.g. etoposide). 2) Role of antioxidant and prooxidant interactions of hemoglobin with nitric oxide during hemorrhage-induced oxidative injury. 3) Development of novel, sensitive and accurate methods for quantitation of oxidative stress.
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