The research focus of Dr. Xie's laboratory is nuclear receptor-mediated transcriptional regulation of genes that encode drug metabolizing enzymes and drug transporters. This regulation has broad implications in drug metabolism and human diseases, such as hepatobiliary diseases, endocrine disorders, metabolic syndrome, and cancers. Dr. Xie’s research is conducted using a combination of cell cultures and genetically engineered mice that include transgenic, knockout and humanized mice. The nuclear receptor we are most interested of include the pregnane X receptor (PXR), constitutive androstane receptor (CAR), liver X receptor (LXR), retinoid-related orphan receptor (ROR), and farnesoid X receptor (FXR). Dr. Xie is the author or coauthor of over 110 journal articles and book chapters and over 120 invited lectures at conferences and universities. Dr. Xie is the sole editor of "Nuclear Receptors in Drug Metabolism," a book published by Wiley. Dr. Xie currently serves ad hoc reviewer for the NIH and DOD Study Sections and for over 60 scientific journals. Among his achievements, Dr. Xie is the recipient of the University of Pittsburgh Chancellor’s Distinguished Research Award, the James R. Gillette International Society for the Study of Xenobiotics (ISSX) North American New Investigator Award, the American Society for Pharmacology and Experimental Therapeutics (ASPET) Division for Drug Metabolism Early Career Achievement Award, and the Joseph Koslow Endowed Chair in Pharmaceutical Sciences.
Back to Top