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Research

I am interested in discovering cancer resistance mechanisms to chemotherapy and new methods to increase treatment efficacy. 

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Publications/Abstracts

Goellner EM, Svilar D, Almeida KH, Sobol RW. “Targeting DNA Polymerase ß for therapeutic intervention” Current Molecular Pharmacology, 2012 5(1):68-87; PMID: 22122465

Tang JB, Svilar D, Trivedi RN, Wang XH, Goellner EM, Moore B, Hamilton RL, Banze LA, Brown AR, and Sobol RW.  N-methylpurine DNA glycosylase and DNA polymerase {beta} modulate BER inhibitor potentiation of glioma cells to temozolomide.  Neuro Oncol. 2011;13(5):471-86. PMID: 21377995

Svilar D, Goellner EM, Almeida KH, Sobol RW. Base Excision Repair and lesion-dependent sub-pathways for repair of oxidative DNA damage” (2010) Antioxidants and Redox Signaling, In Press. Epub 2010 Jul 22 PMID: 20649466

Tang JB, Goellner EM, Wang XH, Trivedi RN, St Croix CM, Jelezcova E, Svilar D, Brown AR, and Sobol RW.  Bioenergetic metabolites regulate base excision repair-dependent cell death in response to DNA damage Molecular Cancer Research. 2010;8(1):67-79.  PMID: 20068071