Courtney Andersen studies the role of estrogen receptor-alpha in ovarian cancer.
Chris Barnes investigates the structural details by which transcription factor activity regulates RNA Polymerase II during the universal process of eukaryotic gene expression.
Soma Jobaggy studies nitrated fatty acid pharmacology and the antioxidant response in hypertensive end-organ damage.
Allison Nagle studies growth factor receptor signaling in breast cancer.
David Osei-Hwedieh studies how hemoglobin mutations such as sickle cell trait affect red blood cell storage integrity and post transfusion survival.
Graduate Course List


    Biology of Signal Transduction
    This course will explore different types of signaling pathways activated by receptor-ligand interactions. Topics to be covered include, but are not limited to: G-protein linked receptors, adenylate cyclases, small GTPases, kinases and phosphatases, nitric oxide, phospholipases, steroid hormone signaling, and pharmacological applications of signaling pathway.

    Cancer Biology and Therapeutics
    This course presents biochemical and clinical aspects of cancer biology and therapy, and is designed for graduate students training in the basic sciences or medicine. The lectures cover: the biology of normal and neoplastic cells, mechanisms of neoplastic transformation, chemical and environmental carcinogenesis, viral oncogensis, breast and prostate cancer, radiotherapy, tumor immunology chemotherapy.

    Directed Study
    This course provides the students an opportunity to carry out a specific laboratory project in any area of interest in pharmacology.

    DNA Repair: Biochemistry to Human Disease
    Cellular responses to DNA damage impact cell cycle control, transcription, replication, cell division, signal transduction and evolution. More than 40 distinct human diseases are caused by defects in DNA repair, including syndromes of impaired development, cancer predisposition or premature aging. This course will emphasize the biochemistry of DNA repair, placing these mechanisms into the context of other cellular processes such as DNA replication, transcription and damage signaling. Sources of DNA damage, both environmental and endogenous will be discussed, as well as the importance of DNA repair during development and to prevent cancer and aging. (only offered in even years-i.e. 2008, 2010, 2012)

    Drug Discovery
    Drug discovery is an interdisciplinary science that identifies small molecule and /or biologic modulators of cell and tissue function. This course will discuss various topics that are relevant to current approaches and principles in drug discovery including target validation, drug origins, cell-based screening, high throughput screening, proteomic approaches to drug discovery, computational biological aspects of drug discovery, and pharmacoinformatics, as well as topics in preclinical drug development and intellectual property. The course will include case studies intended to aid students in a full understanding of the drug discovery process.

    Foundations Conference
    Contemporary approaches to problem-solving in biology, as well as principles underlying modern methods of biomedical research will be integrated with the lecture component of the course through an analysis of mechanisms underlying biological phenomena. Students will present papers, critically analyze data and devise experimental approaches to biomedical problems considered in lecture.

    Foundations of Biomedical Science
    Primary objectives of the course mechanisms controlling cell, tissue and organ function, and to develop an understanding of the experimental evidence supporting these concepts through an integrated presentation of material from biochemistry, cell biology, genetics, immunology, microbiology, neurobiology, pathology, pharmacology, and physiology. The development of critical thinking skills will be emphasized through an evaluation of experimental evidence and reading of the primary literature.

    Full-Time Dissertation Study
    Doctoral candidates who have completed all credit requirements for the degree, including any minimum dissertation credit requirements, and are working full-time on their dissertations may register for this course. While the course carries no credits and no grade, students who enroll in "Full-Time Dissertation Study" are considered by the University to have full-time registration status.

    Introduction to Biocomputing
    This course will provide students with the skills needed to prepare written and oral scientific presentations. Topics to be covered include web browsers, library database searches, use of bibliographic management software, proper citation usage, electronic journal access, use and manipulation of PDF files, PowerPoint presentations, molecular biology databases available on the web, construction and use of relational databases, BLAST searches, nucleic acid sequence analysis programs and molecular structure analysis programs.

    Journal Club (Fall & Spring)
    Journal Club presentations will be held each week that the department hosts a seminar speaker. Students will be required to present a recent research article related to the topic area of  the Departmental Seminar once each year but must attend a minimum of 80% of the Journal Clubs in order to receive credit for the course.

    Lab Research Rotation Supplement
    Course supplement to INTBP 2010 for those students initiating their first rotation in summer.

    Laboratory Research Rotation
    This lab is designed to introduce the student to relevant laboratory methods as well as the layout and conceptualization of experiments. The course will serve to acquaint the student with the laboratory process, and to facilitate his/her selection of a lab for dissertation research. Students are required to register for and complete rotations through three different laboratories, thereby ensuring broad exposure to method and practice.

    Molecular Pharmacology
    This course examines molecular mechanisms of drug interactions with an emphasis on drugs that modulate cell signaling and cellular responses to drugs. The course will include student participation through presentations and discussion of relevant contemporary scientific literature. Topics include: cell cycle checkpoints and anti-cancer drugs, therapeutic control of ion channels, and blood glucose, nonsteroidal anti-inflammatory agents and arachidonic acid signaling, and molecular mechanisms of drug tolerance. Two sessions will be devoted to each topic.

    This course will examine the molecular mechanism of drug action for different classes of drugs including, but not limited to, antidepressants, antipsychotics, antiviral drugs, drugs to relieve pain, diuretics, drugs affecting the cardiovascular system and drugs affecting endocrine systems. In addition, lectures will highlight the most recent developments for treatments of neurodegenerative diseases and psychiatric disorders.

    Ph.D. Dissertation Research
    After advancement to candidacy for the PhD degree, students enroll in this course to pursue original experimental laboratory research, the results of which will provide the substance of their doctoral dissertation. A minimum of 40 credits of this course are required for the PhD degree in the School of Medicine.

    Pharmacology Summer Seminar
    Beginning in the third year of the program students will be required to participate annually in the Departmental Summer Seminar Series. These seminars will be held once a week throughout the summer and will be focused on the student's research plans and recent results. This presentation will be made to an audience with diverse research interests and should therefore include a brief summary of general background information.

    Principles of Pharmacology
    This course consists of a series of lectures and tutorial sessions which focus on the general principles of pharmacology. Major topics are principles of pharmacokinetics (including drug absorption, distribution, and metabolism) and pharmacodynamics (quantitation of drug-receptor interactions).

    Research Seminar
    Beginning in the second year of the program students will be required to attend the Departmental Seminar series. These seminars are held approximately once a week throughout the fall and spring semesters and include presentations by nationally and internationally recognized visiting researchers in pharmacology and related fields. in order to receive credit of the course. students must attend a minimum of 80% of the seminars.

    Scientific Ethics
    The course is an introduction to the basic ethical issues which arise in the course of conducting scientific research. It is intended for graduate students and fellows in the biomedical sciences who have completed at least one year of graduate work. The course will composed of informal lecture presentations followed by discussion of issues in small groups.


11/30/2015 8:30 AM Molecular Pharmacology Journal Club
Ravi Patel

12/1/2015 3:30 PM Pharmacology & Chemical Biology Seminar Series
Laura Stabile, Ph.D., Research Associate Professor

12/7/2015 8:30 AM Molecular Pharmacology Journal Club
Stephanie Mutchler

Pharmacology and Chemical Biology Event Calendar

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