Recent Student Publications

Shireen Attaran

Skoko JJ, Attaran S, Neumann CA. Signals Getting Crossed in the Entanglement of Redox and Phosphorylation Pathways: Phosphorylation of Peroxiredoxin Proteins Sparks Cell Signaling. Antioxidants (Basel). 2019 Jan 23;8(2). pii: E29. doi: 10.3390/antiox8020029. PMID: 30678096 PMCID: PMC6406269

Dennis Braden

Zhu D, Dai W, Srinivasan P, McClellan H, Braden D, Allee-Munoz A, Hurtado PAG, Miller LH, Duffy PE. Characterization of AMA1-RON2L complex with native gel electrophoresis and capillary isoelectric focusing  Electrophoresis. 2021 Oct 22. doi: 10.1002/elps.202000365. Online ahead of print. PMID: 34679212

Caitlyn Chapman

Garrudo FFF, Mikael PE, Xia K, Silva JC, Ouyang Y, Chapman CA, Hoffman PR, Yu Y, Han X, Rodrigues CAV, Cabral JMS, Morgado J, Ferreira FC, Linhardt RJ. The effect of electrospun scaffolds on the glycosaminoglycan profile of differentiating neural stem cells. Biochimie. 2021 Mar;182:61-72. doi: 10.1016/j.biochi.2021.01.001. Epub: 2021 Jan 7.

Jaclyn Connelly

Zhang X, Connelly J, Chao Y, Wang QJ. Multifaceted Functions of Protein Kinase D in Pathological Processes and Human Diseases.   Biomolecules. 2021 Mar 23;11(3):483. doi: 10.3390/biom11030483. PMID: 33807058  PMCID: PMC8005150
Zhang X, Connelly J, Levitan ES, Sun D, Wang JQ. Calcium/Calmodulin-Dependent Protein Kinase II in Cerebrovascular Diseases.  Transl Stroke Res. 2021 Aug;12(4):513-529. doi: 10.1007/s12975-021-00901-9. Epub 2021 Mar 13. PMID: 33713030

Atinuke Dosunmu-Ogunbi

Dosunmu-Ogunbi AM, Wood KC, Novelli EM, Straub AC. Decoding the role of SOD2 in sickle cell disease. Blood Adv. 2019 Sep 10;3(17):2679-2687. doi: 10.1182/bloodadvances.2019000527. PMID: 31506286 PMCID: PMC6737422

Kaylee Ermine

Tong J, Tan X, Risnik D, Gao M, Song X, Ermine K, Shen L, Wang S, Yu J, Zhang L.  BET protein degradation triggers DR5-mediated immunogenic cell death to suppress colorectal cancer and potentiate immune checkpoint blockade. Oncogene. 2021 Oct 6. doi: 10.1038/s41388-021-02041-8. Online ahead of print. PMID: 34615996

Joseph Galley

Galley JC, Hahn SA, Miller MP, Durgin BG, Jackson EK, Stocker SD, Straub AC. Angiotensin II augments renal vascular smooth muscle soluble GC expression via an AT1 receptor-forkhead box subclass O transcription factor signalling axis.  Br J Pharmacol. 2021 May 7. doi: 10.1111/bph.15522. Online ahead of print. PMID: 33963547

Galley JC, Durgin BG, Miller MP, Hahn SA, Yuan S, Wood KC, Straub AC. Antagonism of Forkhead Box Subclass O Transcription Factors Elicits Loss of Soluble Guanylyl Cyclase Expression.  Mol Pharmacol. 2019 Jun;95(6):629-637. doi: 10.1124/mol.118.115386. Epub 2019 Apr 15. PMID: 30988014   PMCID: PMC6527398

Lloyd Harvey

Acharya AP, Tang Y, Bertero T, Tai YY, Harvey LD, Woodcock CC, Sun W, Pineda R, Mitash N, Königshoff M, Little SR, Chan SY.   Simultaneous Pharmacologic Inhibition of Yes-Associated Protein 1 and Glutaminase 1 via Inhaled Poly(Lactic-co-Glycolic) Acid-Encapsulated Microparticles Improves Pulmonary Hypertension.J Am Heart Assoc. 2021 Jun 15;10(12):e019091. doi: 10.1161/JAHA.120.019091. Epub 2021 May 29. PMID: 34056915
Woodcock CC, Hafeez N, Handen A, Tang Y, Harvey LD, Estephan LE, Speyer G, Kim S, Bertero T, Chan SY.     Matrix stiffening induces a pathogenic QKI-miR-7-SRSF1 signaling axis in pulmonary arterial endothelial cells.Am J Physiol Lung Cell Mol Physiol. 2021 May 1;320(5):L726-L738. doi: 10.1152/ajplung.00407.2020. Epub 2021 Feb 10. PMID: 33565360   PMCID: PMC8174827
Harvey LD, Chan SY.   Evolving systems biology approaches to understanding non-coding RNAs in pulmonary hypertension.  J Physiol. 2019 Feb;597(4):1199-1208. doi: 10.1113/JP275855. Epub 2018 Sep 2. PMID: 30113078 PMCID: PMC6375871

Victoria Heinrich

Manni ML, Heinrich VA, Buchan GJ, O’Brien JP, Uvalle C, Cechova V, Koudelka A, Ukani D, Rawas-Qalaji M, Oury TD, Hart R, Ellgass M, Mullet SJ, Fajt ML, Wenzel SE, Holguin F, Freeman BA, Wendell SG. Nitroalkene fatty acids modulate bile acid metabolism and lung function in obese asthma. Scientific Reports. 2021; 11(1): 17788.

Angela Hinchie

Sullivan DI, Jiang M, Hinchie AM, Roth MG, Bahudhanapati H, Nouraie M, et al. Transcriptional and Proteomic Characterization of Telomere-Induced Senescence in a Human Alveolar Epithelial Cell Line. Front Med (Lausanne). 2021;8:600626.
Ren X, Hinchie A, Swomley A, Powell DK, Butterfield DA. Profiles of brain oxidative damage, ventricular alterations, and neurochemical metabolites in the striatum of PINK1 knockout rats as functions of age and gender: Relevance to Parkinson disease. Free Radic Biol Med. 2019 01;143:146–52.

Mohd Azrin bin Jamalruddin

Brunette GJ, Jamalruddin MA, Baldock RA, Clark NL, Bernstein KA.   Evolution-based screening enables genome-wide prioritization and discovery of DNA repair genes.  Proc Natl Acad Sci U S A. 2019 Sep 24;116(39):19593-19599. doi: 10.1073/pnas.1906559116. Epub 2019 Sep 9. PMID: 31501324  PMCID: PMC6765268

Aaron Johnson

G. L. Seim, E. C. Britt, S. V. John, F. J. Yeo, A. R. Johnson, R. S. Eisenstein, D. J. Pagliarini, J. Fan. 2019. Two-stage metabolic remodeling in macrophages in response to LPS and interferon-γ stimulation. Nature Metabolism 2019, 1 (7) 731-742. Pubmed PMID: 322590

Nicole Kaminski

Evgeniia Prokhorova, Thomas Agnew, Anne R Wondisford, Michael Tellier, Nicole Kaminski, Danique Beijer, James Holder, Josephine Groslambert, Marcin J Suskiewicz, Kang Zhu, Julia M Reber, Sarah C Krassnig, Luca Palazzo, Shona Murphy, Michael L Nielsen, Aswin Mangerich, Dragana Ahel, Jonathan Baets, Roderick J O'Sullivan, Ivan Ahel. Unrestrained poly-ADP-ribosylation provides insights into chromatin regulation and human disease. Molecular Cell.2021 Jun 17;81(12):2640-2655.e8.
doi: 10.1016/j.molcel.2021.04.028. Epub 2021 May 20.

Matthew Keeney

Keeney, M. T., Hoffman, E. K., Greenamyre, J. T. and Di Maio, R. (2021). Measurement of LRRK2 Kinase Activity by Proximity Ligation Assay. Bio-protocol 11(17): e4140. DOI: 10.21769/BioProtoc.4140.
Keeney, M.T., Hoffman E.K., Farmer, K., Bodle, C.R., Fazzari, M., Zharikov, A., Castro, S., Kofler, J., Cifuentes-Pagano, E., Pagano, P.J, Burton, E.A, Hastings, T. G., Greenamyre, J. T, & Di Maio, R. (2021). Neuronal NADPH Oxidase 2 in Parkinson’s Disease Pathogenesis. bioRxiv doi:
Rocha EM, De Miranda BR, Castro S, Drolet R, Hatcher NG, Yao L, Smith SM, Keeney MT, Di Maio R, Kofler J, Hastings TG, Greenamyre JT.    LRRK2 inhibition prevents endolysosomal deficits seen in human Parkinson's disease.Neurobiol Dis. 2020 Feb;134:104626. doi: 10.1016/j.nbd.2019.104626. Epub 2019 Oct 13. PMID: 31618685 PMCID: PMC7345850

Jeff (Yong Joon) Kim

Xie, Y., Clarke, B. P., Kim, Y. J., Ivey, A. L., Hill, P. S., Shi, Y., & Ren, Y. (2021). Cryo-EM structure of the yeast TREX complex and coordination with the SR-like protein Gbp2. Elife10, e65699.
Sun, D., Sang, Z., Kim, J., Xiang, Y., Cohen, T., Belford, A. K., ... & Shi, Y. (2021). Potent neutralizing nanobodies resist convergent circulating variants of SARS-CoV-2 by targeting novel and conserved epitopes. bioRxiv. 2021 Mar 10;2021.03.09.434592.
doi: 10.1101/2021.03.09.434592. Preprint

Thong Luong

Bonilla B, Brown AI, Hengel SR, Rapchak KS, Mitchell D, Pressimone CA, Fagunloye AA, Luong TT, Russell RA, Vyas RK, Mertz TM, Zaher HS, Mosammaparast N, Malc EP, Mieczkowski PA, Roberts S, Bernstein KA. The Shu complex prevents mutagenesis and cytotoxicity of single-strand specific alkylation lesions. Elife. 2021 Nov 1;10:e68080. doi: 10.7554/eLife.68080. Epub ahead of print. PMID: 34723799.

Grimley E, Cole AJ, Luong TT, McGonigal SC, Sinno S, Yang D, Bernstein KA, Buckanovich RJ. Aldehyde dehydrogenase inhibitors promote DNA damage in ovarian cancer and synergize with ATM/ATR inhibitors. Theranostics. 2021 Jan 20;11(8):3540-3551. doi: 10.7150/thno.51885. PMID: 33664846; PMCID: PMC7914353.
Baldock RA, Pressimone CA, Baird JM, Khodakov A, Luong TT, Grundy MK, Smith CM, Karpenshif Y, Bratton-Palmer DS, Prakash R, Jasin M, Garcin EB, Gon S, Modesti M, Bernstein KA.  RAD51D splice variants and cancer-associated mutations reveal XRCC2 interaction to be critical for homologous recombination.DNA Repair (Amst). 2019 Apr;76:99-107. doi: 10.1016/j.dnarep.2019.02.008. Epub 2019 Feb 23. PMID: 30836272  PMCID: PMC6508892

Michelle Lynskey

Barroso-González J, García-Expósito L, Hoang SM, Lynskey ML, Roncaioli JL, Ghosh A, Wallace CT, de Vitis M, Modesti M, Bernstein KA, Sarkar SN, Watkins SC, O'Sullivan RJ.  RAD51AP1 Is an Essential Mediator of Alternative Lengthening of Telomeres.   Mol Cell. 2019 Oct 3;76(1):11-26.e7. doi: 10.1016/j.molcel.2019.06.043. Epub 2019 Aug 7. PMID: 31400850  PMCID: PMC6778027

Bellina Mushala

Mushala, B., & Scott, I. (2021). Adropin: a hepatokine modulator of vascular function and cardiac fuel metabolism. American journal of physiology. Heart and circulatory physiology, 320(1), H238–H244.


Raja, S., & Van Houten, B. (2021). The Multiple Cellular Roles of SMUG1 in Genome Maintenance and Cancer.
International journal of molecular sciences, 22(4), 1981.

Hayley Rein

Rein, H.L., Bernstein, K.A., and Baldock, R.A. (2021) RAD51 paralog function in replicative DNA damage and tolerance. Current Opinions in Genetics and Development, 71:86-91
Prakash, R., Sandoval, T., Morati, F., Zagelbaum, J.A., Taylor, B., Wang, R., Desclos, E.C.B., Sullivan, M.R., Rein, H.L., Bernstein, K.A., Krawczyk, P.M., Gautier, J., Modesti, M., Vanoli, F., Jasin, M. (2021) Distinct pathways homologous recombination controlled by the SWS1-SWSAP1-SPIDR complex, Nature Communications, 12(1):4255

Heidi Schmidt

Lewis, S.E., Rosencrance, C.B., DeVallance, E., Giromini, A., Williams, X.M., Oh, J., Schmidt, H.M., Straub, A.C., Chantler, P.D., Patel, R.P., Kelley, E.E., “Human and Rodent Red Blood Cells do not Demonstrate Xanthine Oxidase Activity or XO-Catalyzed Nitrite Reduction to NO,” Free Radical Biology and Medicine (2021).
Dosunmu-Ogunbi, A., Galley, J.C., Yuan, S., Schmidt, H.M., Wood, K.C., Straub, A.C., “Redox Switches Controlling Nitric Oxide Signaling in the Resistance Vasculature and Implications for Blood Pressure Regulation,” Hypertension (2021)
Yuan, S., Schmidt, H.M., Wood, K.C., Straub, A.C., “Coenzyme Q in cellular redox regulation and clinical heart failure”, Free Radical Biology and Medicine. (2021).
Wood KC, Durgin BG, Schmidt HM, Hahn SA, Baust JJ, Bachman T, Vitturi DA, Ghosh S, Ofori-Acquah SF, Mora AL, Gladwin MT, Straub AC.  Smooth muscle cytochrome b5 reductase 3 deficiency accelerates pulmonary hypertension development in sickle cell mice.  Blood Adv. 2019 Dec 10;3(23):4104-4116. doi: 10.1182/bloodadvances.2019000621. PMID: 31821458  PMCID: PMC6963246
Wood, K.C., Durgin, B.G., Schmidt, H.M., Hahn, S.A., Baust, J.J., Bachman, T., Vitturi, D.A., Ghosh, S., Ofori-Acquah, S.F., Mora, A.L., Gladwin, M.T., and Straub, A.C., “Smooth muscle cytochrome b5 reductase 3 deficiency accelerates pulmonary hypertension development in sickle cell mice,” Blood Advances. doi: 10.1182/bloodadvances.2019000621 (2019)
Durgin BG, Hahn SA, Schmidt HM, Miller MP, Hafeez N, Mathar I, Freitag D, Sandner P, Straub AC.   Loss of smooth muscle CYB5R3 amplifies angiotensin II-induced hypertension by increasing sGC heme oxidation. JCI Insight. 2019 Oct 3;4(19):e129183. doi: 10.1172/jci.insight.129183. PMID: 31487266  PMCID: PMC6795404
Durgin, B.G., Hahn, S.A., Schmidt, H.M., Miller, M.P., Hafeez, N., Mathar, I., Freitag, D., Sandner, P., and Straub, A.C., “Loss of smooth muscle CYB5R3 amplifies angiotensin II-induced hypertension by increasing sGC heme oxidation,” JCI Insight. doi: 10.1172/jci.insight.129183. (2019)
Schmidt, H.M., Kelley, E.E., Straub, A.S., “The impact of xanthine oxidase (XO) on hemolytic diseases,” Redox Biology. doi: 10.1016/j.redox.2018.101072 (2018)

Regina Schnegelberger

Lang AL, Krueger AM, Schnegelberger RD, Kaelin BR, Rakutt MJ, Chen L, Arteel GE, Beier JI.  Rapamycin attenuates liver injury caused by vinyl chloride metabolite chloroethanol and lipopolysaccharide in mice.  Toxicol Appl Pharmacol. 2019 Nov 1;382:114745. doi: 10.1016/j.taap.2019.114745. Epub 2019 Sep 6. PMID: 31499194  PMCID: PMC6823165
Wahlang B, Jin J, Beier JI, Hardesty JE, Daly EF, Schnegelberger RD, Falkner KC, Prough RA, Kirpich IA, Cave MC.   Mechanisms of Environmental Contributions to Fatty Liver Disease.  Curr Environ Health Rep. 2019 Sep;6(3):80-94. doi: 10.1007/s40572-019-00232-w. PMID: 31134516 4  PMCID: PMC6698418

Anne Wondisford

Prokhorova E, Agnew T, Wondisford AR, Tellier M, Kaminski N, Beijer D, Holder J, Groslambert J, Suskiewicz MJ, Zhu K, Reber JM, Krassnig SC, Palazzo L, Murphy S, Nielsen ML, Mangerich A, Ahel D, Baets J, O'Sullivan RJ, Ahel I. Unrestrained poly-ADP-ribosylation provides insights into chromatin regulation and human disease. Mol Cell. 2021 Jun 17;81(12):2640-2655.e8. doi: 10.1016/j.molcel.2021.04.028. PMID: 34019811; PMCID: PMC8221567.