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Pharmacology and Chemical Biology Seminar Series

Pharmacology & Chemical Biology Seminar Series
12/8/2022 - 12:00 PM-1:00 PM

Ji Sun, PhD 
Assistant Member
St. Jude Children’s Research Hospital

Gain-of-function mutations in LRRK2 lead to Parkinson’s Disease (PD); therefore, LRRK2 inhibitors hold great potential for PD treatment. In this seminar, Dr. Sun will discuss the structure-function relationship of LRRK2, focusing on the following questions. 1) What is the architecture of LRRK2, a 286-kDa multi-domain protein? 2)  How is LRRK2 recruited to membrane surface by Rab GTPase? 3) How is LRRK2 activated upon membrane recruitment. And 4) What can we learn about LRRK2 PD mutations to guide future drug development?  
 

Pharmacology & Chemical Biology Seminar Series
12/15/2022 - 12:00 PM-1:00 PM

Mikel Garcia-Marcos, PhD 
Professor
Department of Biochemistry
Boston University School of Medicine
 

Our research program aims to understand the mechanisms and consequences cell communication via heterotrimeric G-proteins (Gαβγ) because they represent major intracellular hubs of signaling with very direct biomedical relevance. To achieve this goal, we use a wide range of approaches (biochemistry, cell biology, genetics, drug screening/ development) and experimental systems (purified proteins, cultured cells, model organisms) in combination with the development of novel tools (biosensors, chemogenetics, optogenetics). Our ongoing efforts have direct implications in cancer, embryonic development defects, and neurological disorders.