Pharmacology & Chemical Biology Seminar Series
1/28/2021 - 12:00 PM-1:00 PM
“Unconventional GPCR-G protein coupling”


Nevin Lambert, Ph.D.
Regents’ Professor & Vice Chair for Research
Department of Pharmacology and Toxicology
Augusta University, Medical College of Georgia

Summary: Conventional GPCR-G protein coupling involves a positive allosteric interaction between the agonist-bound state of the receptor and the nucleotide-free state of the G protein. This ternary complex model is the basis for stimulus-response coupling. Recent studies from our lab have uncovered unconventional modes of coupling between GPCRs and G proteins that expand on this model, and suggest that GPCR-G protein interactions are functionally more diverse than previously suspected.


Melanie Hoffner
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