Pharmacology & Chemical Biology Seminar Series
10/8/2020 - 12:00 PM-1:00 PM
“Single-domain antibody fragments as tools to investigate G protein-coupled receptors”

Andrew Kruse, Ph.D.
Professor of Biological Chemistry and Molecular Pharmacology
Harvard Medical School

Single domain antibody fragments have proven to be powerful tools for investigating transmembrane signaling by G protein-coupled receptors (GPCRs) and other proteins. We have developed a fully in vitro platform for antibody fragment discovery by yeast surface display, leading to the discovery of conformational stabilizers and signaling modulators for a prototypical GPCR, the angiotensin receptor. These molecules have enabled new insight into the structural basis for signaling and may serve as therapeutic leads for treatment of cardiovascular disease where small molecule drugs cannot be used.

Melanie McClain
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