Pharmacology & Chemical Biology Seminar Series
11/19/2020 - 12:00 PM-1:00 PM
"Trafficking in CF Therapies"?

*Distinguished Lecturer*

Dean Madden, Ph.D. 
Vice Provost for Research
Professor of Biochemistry & Cell Biology
Dartmouth College/Geisel School of Medicine

CF modulator therapies have provided unprecedented hope for 90% of people with CF. However, they do not achieve full restoration of CFTR activity, and past experience suggests that chronic infections may persist in a significant number of patients, along with GI and other symptoms. So the search is not over. We have identified CFTR endosomal trafficking as a point of intervention that complements existing modulators, and will discuss some novel inhibitor design strategies.

Melanie McClain
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