Pharmacology and Chemical Biology Seminar Series

Pharmacology & Chemical Biology Seminar Series
10/29/2020 - 12:00 PM-1:00 PM

Ieva Sutkeviciute, Ph.D.
Research Assistant Professor
Department of Pharmacology & Chemical Biology
University of Pittsburgh
School of Medicine

Despite being highly important targets for treatment of numerous disorders including metabolic, cardiovascular and psychiatric, the peptide hormone-binding class B G protein-coupled receptors (GPCRs) are notoriously difficult to drug with small molecule drug candidates due to their structural features. We set out to challenge this problem by investigating the druggability of parathyroid hormone type 1 receptor (PTH1R), a prototypical class B GPCR that is a key regulator of mineral ion homeostasis and bone turnover. Using a combination of computational approaches, we identified an allosteric druggable site in PTH1R and discovered several small molecule compounds that effectively modulate PTH-induced PTH1R signaling in cells as well as gene expression in mice long bones. We also demonstrate that such computational pipeline might be extendable to other class B GPCRs to discover novel druggable allosteric sites. 
 

Pharmacology & Chemical Biology Seminar Series
11/5/2020 - 12:00 PM-1:00 PM

Wim Vermeulen, Ph.D. 
Professor of Molecular Genetics
Erasmus MC, Netherlands


Pharmacology & Chemical Biology Seminar Series
11/12/2020 - 12:00 PM-1:00 PM

Carsten Skarke, M.D. 
Research Assistant Professor
Institute for Translational Medicine and Therapeutics
University of Pennsylvania Perelman School of Medicine


Pharmacology & Chemical Biology Seminar Series
11/19/2020 - 12:00 PM-1:00 PM

Dean Madden, Ph.D. 
Vice Provost for Research
Professor of Biochemistry & Cell Biology
Dartmouth College/Geisel School of Medicine


 

Pharmacology & Chemical Biology Seminar Series
12/3/2020 - 12:00 PM-1:00 PM

Braulio Bonilla 
Graduate Student Researcher