Shiva Lab

Sruti Shiva, PhD
Associate Professor & Vice Chair for Academics

Sruti Shiva, PhD

Xu W, N Cardenes, C Corey, SC Erzurum and S Shiva.  Platelets from asthmatic individuals show less reliance on glycolysis.  PLoS One 10:e0132007, 2015.
Khoo NK, L Mo, S Zharikov, C Kamga-Pride, K Quesnelle, F Golin-Bisello, L Li, Y Wang and S Shiva.  Nitrite augments glucose intake in adipocytes through the protein kinase A-dependent stimulation of mitochondrial fusion.  Free Radic Biol Med 70:45-53, 2014.
Cardenes N, C Corey, L Geary, S Jain, S Zharikov, S Barge, EM Novelli and S Shiva.  Platelet bioenergetic screen in sickle cell patients reveals mitochondrial complex V inhibition, which contributes to platelet activation.  Blood 123:2864-2872, 2014.
Kamga Pride C, L Mo, K Quesnelle, RK Dagda, D Murillo, L Geary, C Corey, R Portella, S Zharikov, C St. Croix, S Maniar, CT Chu, NK Khoo and S Shiva.  Nitrite activates protein kinase A in normoxia to mediate mitochondrial fusion and tolerance to ischaemia/reperfusion.  Cardiovasc Res 101:57-68, 2014.
Zharikov S and S Shiva.  Platelet mitochondrial function:  From regulation of thrombosis to biomarker of disease.  Biochem Soc Trans 41:118-123, 2013.
Shiva S, Z Huang, R Grubina, LA Ringwood, PH MacArthur, W Xu, VM Darley-Usmar and MT Gladwin.  Deoxymyoglobin is a nitrite reductase that generates NO and regulates mitochondrial function. Circ Res 100:654-661, 2007.
Shiva S, X Wang, LA Ringwood, X Xu, S Yuditskaya, V Annavajjhala, H Miyajima, N Hogg, ZL Harris and MT Gladwin.  Ceruloplasmin is a nitric oxide oxidase and nitrite synthase that determines endocrine NO homeostasis.  Nat Chem Bio 2:486-493, 2006.