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Pharmacology and Chemical Biology Seminar Series
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Seminar Series
Pharmacology & Chemical Biology Seminar Series
12/8/2022 - 12:00 PM-1:00 PM
“Structural basis of LRRK2 activation – a molecular paradigm of kinase spatial regulation”
Ji Sun, PhD
Assistant Member
St. Jude Children’s Research Hospital
Gain-of-function mutations in
LRRK2
lead to Parkinson’s Disease (PD); therefore, LRRK2 inhibitors hold great potential for PD treatment. In this seminar, Dr. Sun will discuss the structure-function relationship of LRRK2, focusing on the following questions. 1) What is the architecture of LRRK2, a 286-kDa multi-domain protein? 2) How is LRRK2 recruited to membrane surface by Rab GTPase? 3) How is LRRK2 activated upon membrane recruitment. And 4) What can we learn about LRRK2 PD mutations to guide future drug development?
Pharmacology & Chemical Biology Seminar Series
12/15/2022 - 12:00 PM-1:00 PM
“The secret life of G proteins”
Mikel Garcia-Marcos, PhD
Professor
Department of Biochemistry
Boston University School of Medicine
Our research program aims to understand the mechanisms and consequences cell communication via heterotrimeric G-proteins (Gαβγ) because they represent major intracellular hubs of signaling with very direct biomedical relevance. To achieve this goal, we use a wide range of approaches (biochemistry, cell biology, genetics, drug screening/ development) and experimental systems (purified proteins, cultured cells, model organisms) in combination with the development of novel tools (biosensors, chemogenetics, optogenetics). Our ongoing efforts have direct implications in cancer, embryonic development defects, and neurological disorders.
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