Jonathan Pacheco Romero, PhD

Dr. Pacheco's research focuses on the dynamic regulation of G protein-coupled receptors (GPCRs), particularly delving into the intricate workings of the parathyroid hormone receptor (PTHR). He employs single-molecule visualization techniques and live cell imaging to explore the spatial and temporal organization of PTHR and its regulatory proteins, aiming to unravel the complexities of G-protein mediated signaling pathways. Furthermore, Dr. Pacheco utilizes advanced high-throughput methods, such as Förster resonance energy transfer (FRET) and bioluminescence resonance energy transfer (BRET), to understand the molecular structure and cellular interactions involved in ligand-receptor binding within the PTHR. His comprehensive research endeavors seek to shed light on PTHR functionality and its implications in comprehending and manipulating cellular signaling pathways.