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“Nucleotide Excision Repair, through the looking g...
Pharmacology & Chemical Biology Seminar Series
11/5/2020 - 12:00 PM-1:00 PM
“Nucleotide Excision Repair, through the looking glass”
Wim Vermeulen, Ph.D.
Professor of Molecular Genetics
Erasmus MC, Netherlands
Global genome Nucleotide excision repair (GG-NER) is initiated by the concerted action of the damage sensing protein complexes UV-DDB and XPC. We showed that at this initial stage a reciprocal coordination, controlled by dynamic ubiquitylation, between DNA damage recognition and verification within NER is required for efficient repair.
Contact
Melanie McClain
412/383-7757