Pharmacology & Chemical Biology Seminar Series
10/15/2020 - 12:00 PM-1:00 PM
“Towards tolerance: benzodiazepine induced neuroplasticity”

Tija Jacob, Ph.D. 
Associate Professor
Dept. of Pharmacology & Chemical Biology
University of Pittsburgh School of Medicine

GABAAR are the sites of action of many clinically important drugs, including the benzodiazepines (BZs), which are front line treatments for anxiety, insomnia, schizophrenia and epilepsy. Although effective, BZ use is limited by the development of tolerance, dependence, and withdrawal. The Jacob lab is investigating modulation of GABAAR trafficking and inhibition by BZs and other GABAAR targeted drugs.  More broadly, we are applying biochemical, proteomic, novel optical methods and electrophysiological approaches to identify neuroadaptations induced by BZ treatment both at excitatory and inhibitory synapses.


Melanie McClain
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