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“Pharmacological studies of rhodopsin metabolism”
Pharmacology & Chemical Biology Seminar Series
2/25/2021 - 12:00 PM-1:00 PM
“Pharmacological studies of rhodopsin metabolism”
Yuanyuan Chen, Ph.D.
Assistant Professor of Ophthalmology
University of Pittsburgh
Rod photoreceptors are a couple of dim-light vision responsible neurons expressing a high level of rhodopsin, a class A G protein-coupled receptor which is also the visual pigment. Misfolding of rhodopsin due to genetic mutations lead to rod death and a visual impairment called retinitis pigmentosa. No effective treatment is currently available for this blinding disease. We are using pharmacological approaches to restore rhodopsin protein homeostasis by either stabilizing its native structure with chaperones or inducing the selective clearance of its misfolded aggregation so that rod cells can be rescued, and vision preserved. The implications from our study can bring insights to studies of other proteinopathies.
Contact
Melanie Hoffner
412/383-7757