Xuejing Zhang, PhD

Research Instructor

E1311 Thomas E. Starzl Biomedical Science Tower
200 Lothrop Street
Pittsburgh, PA 15261
Phone: 412-383-7734

Education

B.S. (Bioengineering), Beijing Institute of Technology, Beijing, China, 2007
Ph.D. (Molecular Biology), Southern Illinois University, Springfield, IL, 2012
Xuejing Zhang, PhD
Dr. Zhang works in Wang (Jane) lab. Dr. Wang’s lab conducts basic and translational research on oncogenic protein kinases in the area of cancer biology. The main focus is on diacylglycerol (DAG)-targeted protein kinases, particularly protein kinase D (PKD) and protein kinase C (PKC) family kinases. DAG is a key second messenger generated in cells in response to the activation of receptor tyrosine kinases and G protein-coupled receptors. It acts to disseminate vital signals from the cell surface to the cell interior. PKD and PKC are primary targets of DAG that regulate many fundamental cellular processes such as cell growth, survival, apoptosis, motility, and protein trafficking. In particular, PKD is at the center of the DAG signaling network, integrating signals from both DAG and PKC. In recent years, PKD has emerged as a promising therapeutic target for several diseases including cancer and heart disease. Deregulated PKD expression and activity have been demonstrated in a variety of pathological conditions, suggesting an active contribution to disease initiation and progression.
 

Journal Articles

Zhang X, Hamblin MH and Yin KJ. Noncoding RNAs and stroke. Neuroscientist 25:22-26, 2019.
Zhang X, Tang X, Hamblin MH and Yin K-J. Long non-coding RNA Malat1 regulates angiogenesis in hindlimb ischemia. Int. J. Mol. Sci. 19:1723, 2018.
Tan Z, Li J, Zhang X, Yang X, Zhang Z, Yin KJ and Huang H. TP53 promotes retinoid acid-induced smooth muscle cell differentiation by targeting myocardin. Stem Cells Dev 27:534-544, 2018.
Zhang X, Hamblin MH and Yin K-J. The long noncoding RNA Malat1: Its physiological and pathophysiological functions. RNA Biol 14:1705-1714, 2017.
Zhang X, Tang X, Liu K, Hamblin MH and Yin K-J. Long non-coding RNA Malat1 regulates cerebrovascular pathologies in ischemic stroke. Journal of Neuroscience 37:1797-1806, 2017.
Zhang J, Yuan L, Zhang X, Hamblin MH, Zhu T, Meng F, Li Y, Chen YE, Yin KJ. Altered long non-coding RNA transcriptomic profiles in brain microvascular endothelium after cerebral ischemia. Exp Neurol 277:162-170, 2016.
Dong W, Zhang X, Liu W, Chen Y-J, Huang J, Austin E, Celotto AM, Jiang WZ, Palladino MJ, Jiang Y and Hong Y. An evolutionarily conserved polybasic domain mediates the plasma membrane targeting of Lgl and its regulation by hypoxia. Journal of Cell Biology 211:273-286, 2015.