Jack Lancaster, PhD

Professor

E1344 Thomas E. Starzl Biomedical Science Tower
Pittsburgh, PA 15261
Phone: 412-383-8012
Fax: 412-648-2229

Education

B.Sc. (Chemistry), University of Tennessee at Martin, 1970 Ph.D. (Biochemistry), University of Tennessee Center for the Health Sciences, Memphis, 1974
Jack Lancaster, PhD

Dr. Lancaster’s present research interests are in the chemical and physical foundations of the biological actions of reactive oxygen and nitrogen species. His most recent project is delineating the cellular functions of dinitrosyliron complexes (DNIC), which show a characteristic signal using electron  paramagnetic resonance (EPR) spectroscopy and have been observed in tissues since the 1960’s in a huge variety of pathophysiological conditions. These species contain one iron with two molecules of bound nitric oxide (NO) but the complete molecular structures of these species are essentially unknown, as are possible biological functions. We recently reported data suggesting the cellular origin of the iron and also evidence for two cellular functions, formation of protein nitrosothiols and also protection against cellular injury as a result of hypoxia-induced iron mobilization and consequent oxidative stress (Li et al. J. Biol. Chem. 2014, in press).

www.doctorno.org

 

 

Journal Articles

Li Q, C Li, HK Mahtani, J Du, AR Patel and JR Lancaster.  Nitrosothiol formation and protection against fenton chemistry by nitric oxide-induced dinitrosyliron complex formation from anoxia-initated cellular chelatable iron increase.  J Biol Chem 289:19917-19927, 2014.
Li Q and JR Lancaster.  Chemical foundations of hydrogen sulfide biology.  Nitric Oxide Biology and Chemistry 35:21-34, 2013.
Lancaster JR.  Protein cysteine thiol nitrosation:  Maker or marker of reactive nitrogen species-induced nonerythroid cellular signaling.  Nitric Oxide 19:68, 2008.
Lancaster JR.  Nitroxidative, nitrosative and nitrative stress:  Kinetic predictions of reactive nitrogen species chemistry under biological conditions.  Chem Res Toxicol 19:1160, 2006.
Lancaster JR.  Simulation of the diffusion and reaction of endogenously produced nitric oxide.  Proc Natl Acad Sci USA 91:8137-9141, 1994.
Reddy D, JR Lancaster and DP Cornforth.  Nitrite inhibition of Clostridium botulinum:  Electron spin resonance detection of iron-nitric oxide complexes.  Science 221:769-770, 1983.
Lancaster JR.  New biological paramagnetic center:  Octahedrally coordinated Ni(III) in the methanogenic bacteria.  Science 216:1324-1325, 1982.

Sponsored Research

Hydrogen Sulfide and Tuberculosis Disease - 8/22/2018 - 7/31/2022
University of Alabama at Birmingham - R01AI134810