Jonathan M. Beckel, PhD

Research Assistant Professor

E1352 Thomas E. Starzl Biomedical Science Tower
Pittsburgh, PA 15261
Phone: 412-383-5004
Fax: 412-648-1945

Education

B.S. (Molecular Biology/Biochemistry), University of Pittsburgh, 1998 Ph.D. (Molecular Pharmacology), University of Pittsburgh School of Medicine, 2009 Postdoctoral Fellow, University of Pennsylvania, 2010-2013 Postdoctoral Scholar, University of Pittsburgh, 2013-2015
Jonathan M. Beckel, PhD

Dr. Beckel’s research focuses on the control of the urinary bladder; specifically how the bladder epithelium (also called the urothelium) participates in the sensory limb of the micturition reflex. The ultimate goal of this research is to understand how the urothelium and bladder afferent nerves communicate with each other to transmit sensory information about the bladder to the central nervous system and how changes in this communication play a role in the increased urgency and/or pain often felt by patients suffering from conditions such as overactive bladder (OAB) or Interstitial Cystitis/Painful Bladder Syndrome (IC/PBS). Recent research has focused on the role of purinergic signaling mechanisms in bladder pathology and the release of ATP from urothelial cells through 1) pannexin channels or 2) vesicular release from secretory lysosomes.  

Journal Articles

Coffey EE, Beckel JM, Laties AM and Mitchell CH. Lysosomal alkalization and dysfunction in fibroblasts with the Alzheimer’s disease-linked presenilin-1 A246E mutation can be reversed with cAMP. Neuroscience 263:111-124, 2014.
Beckel JM, Argall AJ, Lim JC, Xia J, Lu W, Macarak EJ, Shahidullah M, Delamere NA, Zode GS, Sheffield VC, Laties AM and Mitchell CH. Mechanosensitive release of adenosine 5'-triphosphate through pannexin channels and mechanosensitive upregulation of pannexin channels in optic nerve head astrocytes: A mechanism for purinergic involvement in chronic strain. Glia 62:1486-1501, 2014.
Guha S, Coffey EE, Lu W, Lim JC, Beckel JM, Laties AM, Boesze-Battaglia K and   Mitchell CH. Approaches for detecting lysosomal alkalinization and impaired degradation in fresh and cultured RPE cells: Evidence for a role in retinal degenerations. Experimental Eye Research 126: 68-76, 2014.
Zhang X, Beckel JM, Daugherty SL, Wang T, Freeman BA, Woodcock S and de Groat WC. Activation of TRPC channels contributes to OA-NO2 induced responses in guinea pig neurons. Journal of Physiology 592 (Pt 19): 4297-4312, 2014.
Guha S, Baltazar GC, Coffey EE, Tu L-A, Lim JC, Beckel JM, Eysteinsson T, Lu W, O’Brien-Jenkins A, Patel S, Laties AM and Mitchell CH. Lysosomal alkalinization, lipid oxidation, impaired autophagy and reduced phagosome clearance triggered by P2X7 receptor activation in retinal pigmented epithelial cells. FASEB Journal 27: 4500-4509, 2013.
Xia J, Lim JC, Lu W, Beckel JM, Macarak EJ, Laties AM and Mitchell CH. Neurons respond directly to mechanical deformation with pannexin-mediated ATP release and autostimulation of P2X7 receptors. Journal of Physiology 590: 2285-2304, 2012.

Sponsored Research

Underlying mechanisms controlling urothelial ATP release and their contributions to urinary bladder physiology and pathophysiology - 8/20/2018 - 5/31/2023
NIH - R01 DK117884
RELIEPH for Interstitial Cystitis - 7/1/2018 - 3/31/2023
NIH - R01DK117383
The Lysosome as an ATP Source in the Urothelium and its Role in Pathology - 7/1/2017 - 6/30/2020
NIH - R03DK114492-01