Van Houten Lab

Dr. Van Houten's group studies the structure and function of DNA repair enzymes, the global responses to stress and the consequences of mitochondrial DNA damage.

Emily Beckwitt
Graduate Student Researcher

Maria Beecher

Namrata Kumar
Graduate Student Researcher

Megan Mahlke, PhD
Postdoctoral Associate

Ben Van Houten, PhD

Ben Van Houten, PhD

Journal Articles

CD Hughes, H Wang, H Ghodke, M Simons, A Towheed, Y Peng, B Van Houten and NM Kad. Real-time single-molecule imaging reveals a direct interaction between UvrC and UvrB on DNA tightropes.  Nucleic Acids Res 41:4901-4912, 2013.
C Haugen, NA DiProspero, JS Parker, RD Fannin, J Chou, JN Meyer, C Halweg, JB Collins, A Durr, K Fischbeck and B Van Houten.  Altered gene expression and DNA damage in peripheral blood cells from Friedreich's ataxia patients:  Cellular model of pathology.  PLoS Genetics 6:e1000812, 2010.
NM Kad, H Wang, GG Kennedy, DM Warshaw and B Van Houten.  Collaborative dynamic DNA scanning by nucleotide excision repair proteins investigated by single-molecule fluorescence imaging of quantum dot labeled proteins.  Molecular Cell 37:702-713, 2010.
SC Wolski, J Kuper, P Hänzelmann, J Truglio, D Croteau, B Van Houten and C Kisker. Crystal structure of the FeS cluster containing nucleotide excision repair helicase XPD. Plos Biology 6:e149, 2008.
H Wang, I Tessmer, DL Croteau, DA Erie and B Van Houten. Functional characterization and atomic force microscopy of a DNA repair protein conjugated to a quantum dot. Nano Lett 8:1631-1637, 2008.
JJ Truglio, E Karakas, B Rhau, H Wang, M DellaVecchia, B Van Houten and C Kisker.  Structural basis of DNA damage recognition and processing by UvrB. Nature Structural & Molecular Biology 13:360-364, 2006.
 JH Santos, L Hunakova, Y Chen, C Bortner and B Van Houten. Cell sorting experiments link persistent mitochondrial DNA damage with loss of mitochondrial membrane potential and apoptotic cell death. J Biol Chem 278:1728-1734, 2003.
FM Yakes and B Van Houten. Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress.  Proc Natl Acad Sci USA 94:514-519, 1997.