Pharmacology & Chemical Biology Seminar Series
12/2/2021 - 12:00 PM-1:00 PM
"Regulation of the RECQL4 Family during the DNA Damage Response"

Thong The Luong 
Grad Student, Bernstein Lab
Pharmacology & Chemical Biology
University of Pittsburgh

Human RECQL4 is a member of the RecQ family of DNA helicases and functions during DNA replication and repair. RECQL4 mutations are associated with developmental defects and cancer. Although RECQL4 mutations lead to disease, RECQL4 overexpression is also observed in cancer, including breast and prostate. Thus, tight regulation of RECQL4 protein levels is crucial for genome stability. Because mammalian RECQL4 is essential, how cells regulate RECQL4 protein levels is largely unknown. In this presentation, I'll be going from yeast to man discussing the function and regulation of the RECQL4 family during repair of cisplatin-induced lesions. 

Melanie L Hoffner
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