Bisello Lab

The general scientific theme in the laboratory is to define the role of accessory proteins (such as arrestins, caveolin, EBP50/NHERF1) in determining G protein-coupled receptor function. Our efforts focus on three areas: 1.) The signaling, trafficking and regulation of the parathyroid hormone type 1 receptor (PTH1) and its function on ion homeostasis and bone metabolism. 2.) The role of PTH1 and PTH2 receptors in vascular smooth muscle cells, with particular emphasis on their role in mitogenesis. 3.) Cellular regulation of the glucagon-like peptide 1 receptor and its role in regulating beta cell function, proliferation and survival.

Dr. Alessandro Bisello
Associate Professor

Dr. Alessandro Bisello

Leslie KL, GJ Song, S Barrick, VL Wehbi, JP Vilardaga, PM Bauer and A Bisello.  Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) and nuclear factor kB (NF-kB):  A feed-forward loop for systemic and vascular inflammation.  J Biol Chem 288:36426-36436, 2013.
Al Ghouleh I, G Frazziano, AI Rodrigues, G Csanyi, S Maniar, CM St. Croix, EE Kelley, LA Egana, GJ Song, A Bisello, YJ Lee and PJ Pagano.  Aquaporin 1, Nox1 and Ask1 mediate oxidant-induced smooth muscle cell hypertrophy.  Cardiovasc Res 97:134-142, 2013.
Wang B, CK Means, Y Yang, T Mamonova, A Bisello, DL Altschuler, JD Scott and PA Friedman.  Ezrin-anchored protein kinase A coordinates phosphorylation-dependent disassembly of a NHERF-1 ternary complex to regulate hormone-sensitive phosphate transport.  J Biol Chem 287:24148-14163, 2012.
Song GJ, S Barrick, KL Leslie, PM Bauer, V Alonso, PA Friedman, NM Fiaschi-Taesch and A Bisello.  The scaffolding protein EBP50 promotes vascular smooth muscle cell proliferation and neointima formation by regulating Skp2 and p21cip1.  Arterioscler Thromb Vasc Biol 32:33-41, 2012.
Song GJ, KL Leslie, S Barrick, S Bougoin, JM Taboas and A Bisello.  EBP50 promotes focal adhesion turnover and vascular smooth muscle cells migration.  J Mol Cell Cardio 53:809-819, 2012.
Song GJ, S Barrick, KL Leslie, B Sicari, NM Fiaschi-Taesch and A Bisello.  EBP50 inhibits the anti-mitogenic action of the parathyroid hormone type 1 receptor in vascular smooth muscle cells.  J Mol Cell Cardiol 49:1012-2021, 2010.
Song GJ, N Fiaschi-Taesch and A Bisello. Endogenous parathyroid hormone-related protein regulates the expression of PTH type 1 receptor and proliferation of vascular smooth muscle cells. Mol Endocrinol 23:1681-1690, 2009.
Syme CA, L Zhang and A Bisello. A. Caveolin-1 regulates cellular trafficking and function of the glucagon-like peptide 1 receptor. Molecular Endocrinology 20:3400-3411, 2006.