Pharmacology and Chemical Biology Seminar Series

Pharmacology & Chemical Biology Seminar Series
2/3/2022 - 12:00 PM-1:00 PM

Mariana X. Byndloss, DVM, PhD 
Assistant Professor
Department of Pathology, Microbiology, and Immunology
Vanderbilt Univ Medical Center

Recent research has demonstrated that the gut microbiota, the largest microbial community inhabiting our body, plays a crucial role in the pathogenesis of various diseases, ranging from cardiovascular disease and cancer to neuropathies. Although exciting, the microbiota field is in its infancy, and little is known about how this complex community and its host interact with one another. The research in Dr. Byndloss' laboratory proposes establishing novel molecular mechanisms responsible for the imbalance in the microbial community (dysbiosis), which connects significant players in chronic inflammatory diseases' pathogenesis. Dr. Byndloss is particularly interested in how inflammation-mediated changes in intestinal epithelial function lead to gut dysbiosis and increased risk of chronic inflammatory disorders, namely obesity,  cardiovascular disease, and colorectal cancer. 


 

Pharmacology & Chemical Biology Seminar Series
2/10/2022 - 12:00 PM-1:00 PM

Agnel Sfeir, PhD 
PaineWebber Chair in Cancer Genetics
Professor and Member – Sloan Kettering Institute

Chromosomes are the fundamental structural units of our genome. The Sfeir lab seeks to understand basic chromosome biology and how their mismanagement manifests in disease. Our research is focused on three major areas: telomere maintenance, nuclear DNA repair, and mitochondrial DNA replication and repair. In the lab address fundamental questions related to telomere maintenance and how telomere dysfunction impacts cancer. In addition, we study an ancient yet error-prone DNA repair pathway, termed micro-homology mediated end-joining (MMEJ), and focus on polymerase theta (Polq), a key enzyme underlying mutagenic repair. Lastly, we investigate replication and repair of mitochondrial genomes and explore mitochondrial-nuclear crosstalk in response to mitochondrial DNA stress.
 

Pharmacology & Chemical Biology Seminar Series
2/17/2022 - 12:00 PM-1:00 PM

Warren Hirst, PhD
Senior Director
Biogen

Over the past 20 years there has been considerable progress in the understanding the genetic basis of Parkinson’s disease (PD).  The genetics have complemented human pathology and we now have an increased knowledge of the disease pathophysiology with lysosomal dysfunction, endosomal trafficking, mitochondrial quality control and immune response being the predominant pathways linked to PD.  This has provided us with well validated therapeutic targets, including a-synuclein, LRRK2, GBA and Parkin.  I will present and discuss the opportunities and challenges of developing novel therapeutics to these targets and how we are linking familial and sporadic forms of the disease in preclinical research and in clinical development.

 

Pharmacology & Chemical Biology Seminar Series
2/24/2022 - 12:00 PM-1:00 PM

Nancy Kanagy, PhD 
Professor and Chair
Deptartment of Cell Biology & Physiology
UNM-HSC School of Medicine


Pharmacology & Chemical Biology Seminar Series
3/3/2022 - 12:00 PM-1:00 PM

Dandan Sun, MD, PhD 
Professor
Depertment of Neurology
University of Pittsburgh


Pharmacology & Chemical Biology Seminar Series
3/17/2022 - 12:00 PM-1:00 PM

Nicole Kaminski 
PhD Candidate, O’Sullivan Lab
University of Pittsburgh
School of Medicine


Pharmacology & Chemical Biology Seminar Series
3/24/2022 - 12:00 PM-1:00 PM

Raquel Buj-Gomez, PhD
Research Instructor
University of Pittsburgh School of Medicine


Pharmacology & Chemical Biology Seminar Series
3/31/2022 - 12:00 PM-1:00 PM

Ruobo Zhou, PhD
Assistant Professor of Chemistry
Penn State, Eberly College of Science


Pharmacology & Chemical Biology Seminar Series
4/7/2022 - 12:00 PM-1:00 PM

Sonja Plasil 
Molecular Pharmacology PhD Candidate
Homanics Lab
Dept of Pharmacology & Chemical Biology


Pharmacology & Chemical Biology Seminar Series
4/14/2022 - 12:00 PM-1:00 PM

Michelle Manni, PhD
Research Assistant Professor
Division of Pulmonary Medicine
Dept of Pediatrics
UPMC Children’s Hospital of Pittsburgh


Pharmacology & Chemical Biology Seminar Series
4/21/2022 - 12:00 PM-1:00 PM

Dennis Braden
Neumann Laboratory
Magee-Womens Research Institute


Pharmacology & Chemical Biology Seminar Series
5/12/2022 - 12:00 PM-1:00 PM

Dennis Stuehr, PhD 
Professor
Cleveland Clinic
Lerner Research Institute