Current Students' Publications

Jaclyn Connelly

Journal Articles

Zhang X, Connelly J, Chao Y, Wang QJ. Multifaceted Functions of Protein Kinase D in Pathological Processes and Human Diseases.   Biomolecules. 2021 Mar 23;11(3):483. doi: 10.3390/biom11030483. PMID: 33807058  PMCID: PMC8005150
 
Zhang X, Connelly J, Levitan ES, Sun D, Wang JQ. Calcium/Calmodulin-Dependent Protein Kinase II in Cerebrovascular Diseases.  Transl Stroke Res. 2021 Aug;12(4):513-529. doi: 10.1007/s12975-021-00901-9. Epub 2021 Mar 13. PMID: 33713030
 

Atinuke Dosunmu-Ogunbi

Journal Articles

Dosunmu-Ogunbi AM, Wood KC, Novelli EM, Straub AC. Decoding the role of SOD2 in sickle cell disease. Blood Adv. 2019 Sep 10;3(17):2679-2687. doi: 10.1182/bloodadvances.2019000527. PMID: 31506286 PMCID: PMC6737422
 

Kulkarni, S., Dolezal, J. M., Wang, H., Jackson, L., Lu, J., Frodey, B. P., Dosunmu-Ogunbi A, Li Y., Fromherz M., Kang A., Santana-Santos L., Benos P., Prochownik, E. V. (2017). Ribosomopathy-like properties of murine and human cancers. PLoS ONE12(8)PMCID: PMC5562309
 

Mohan, S., Das, D., Bauer, R. J., Heroux, A., Zalewski, J. K., Heber, S., Dosunmu-Ogunbi A.M., Trakselis M., Hildebrand J., VanDemark, A. P. (2013). Structure of a Highly Conserved Domain of Rock1 Required for Shroom-Mediated Regulation of Cell Morphology. PLoS ONE8(12)PMCID: PMC3857177


Joseph Galley

Journal Articles

Galley JC, Hahn SA, Miller MP, Durgin BG, Jackson EK, Stocker SD, Straub AC. Angiotensin II augments renal vascular smooth muscle soluble GC expression via an AT1 receptor-forkhead box subclass O transcription factor signalling axis.  Br J Pharmacol. 2021 May 7. doi: 10.1111/bph.15522. Online ahead of print. PMID: 33963547

 
Galley JC, Durgin BG, Miller MP, Hahn SA, Yuan S, Wood KC, Straub AC. Antagonism of Forkhead Box Subclass O Transcription Factors Elicits Loss of Soluble Guanylyl Cyclase Expression.  Mol Pharmacol. 2019 Jun;95(6):629-637. doi: 10.1124/mol.118.115386. Epub 2019 Apr 15. PMID: 30988014   PMCID: PMC6527398
 
Alvarez RA, Miller MP, Hahn SA, Galley JC, Bauer E, Bachman T, Hu J, Sembrat J, Goncharov D, Mora AL, Rojas M, Goncharova E, Straub AC.   Targeting Pulmonary Endothelial Hemoglobin α Improves Nitric Oxide Signaling and Reverses Pulmonary Artery Endothelial Dysfunction.  Am J Respir Cell Mol Biol. 2017 Dec;57(6):733-744. doi: 10.1165/rcmb.2016-0418OC. PMID: 28800253  PMCID: PMC5765416

 
Galley JC, Straub AC.   Redox Control of Vascular Function.  Arterioscler Thromb Vasc Biol. 2017 Dec;37(12):e178-e184. doi: 10.1161/ATVBAHA.117.309945. PMID: 29162599  PMCID: PMC5751756
 

Lloyd Harvey

Journal Articles

Acharya AP, Tang Y, Bertero T, Tai YY, Harvey LD, Woodcock CC, Sun W, Pineda R, Mitash N, Königshoff M, Little SR, Chan SY.   Simultaneous Pharmacologic Inhibition of Yes-Associated Protein 1 and Glutaminase 1 via Inhaled Poly(Lactic-co-Glycolic) Acid-Encapsulated Microparticles Improves Pulmonary Hypertension.J Am Heart Assoc. 2021 Jun 15;10(12):e019091. doi: 10.1161/JAHA.120.019091. Epub 2021 May 29. PMID: 34056915
 
Woodcock CC, Hafeez N, Handen A, Tang Y, Harvey LD, Estephan LE, Speyer G, Kim S, Bertero T, Chan SY.     Matrix stiffening induces a pathogenic QKI-miR-7-SRSF1 signaling axis in pulmonary arterial endothelial cells.Am J Physiol Lung Cell Mol Physiol. 2021 May 1;320(5):L726-L738. doi: 10.1152/ajplung.00407.2020. Epub 2021 Feb 10. PMID: 33565360   PMCID: PMC8174827
 
Harvey LD, Chan SY.   Evolving systems biology approaches to understanding non-coding RNAs in pulmonary hypertension.  J Physiol. 2019 Feb;597(4):1199-1208. doi: 10.1113/JP275855. Epub 2018 Sep 2. PMID: 30113078 PMCID: PMC6375871
Harvey LD, Chan SY.     YAPping About Glutaminolysis in Hepatic Fibrosis.Gastroenterology. 2018 Apr;154(5):1231-1233. doi: 10.1053/j.gastro.2018.03.007. Epub 2018 Mar 3. PMID: 29510133
PMCID: PMC6456336
 
Ranchoux B, Harvey LD, Ayon RJ, Babicheva A, Bonnet S, Chan SY, Yuan JX, Perez VJ.   Endothelial dysfunction in pulmonary arterial hypertension: an evolving landscape (2017 Grover Conference Series).  Pulm Circ. 2018 Jan-Mar;8(1):2045893217752912. doi: 10.1177/2045893217752912. Epub 2017 Dec 28. PMID: 29283043 PMCID: PMC5798691

 

Harvey LD, Chan SY. Emerging metabolic therapies in pulmonary arterial hypertension. J Clin Med. 2017;6(4). PubMed PMID: 28375184; PubMed Central PMCID: PMC5406775.

Harvey L, Yin Y, Attarwala IY, Begum G, Deng J, Yan HQ, Dixon CE, Sun D. Administration of DHA reduces ER stress-associated inflammation and alters microglial or macrophage activation in traumatic brain injury. ASN Neuro. 2015;7(6). PubMed PMID: 26685193; PubMed Central PMCID: PMC4710127.

Zonouzi M, Scafidi J, Li P, McEllin B, Edwards J, Dupree JL, Harvey L, Sun D, Hubner CA, Cull-Candy SG, Farrant M, Gallo V. GABAergic regulation of cerebellar NG2 cell development is altered in perinatal white matter injury. Nature Neuroscience. 2015;18(5):674-82. Epub 2015/03/31. doi: 10.1038/nn.3990. PubMed PMID: 25821912; PubMed Central PMCID: PMC4459267.

Begum G*, Harvey L*, Dixon CE, Sun D. ER stress and effects of DHA as an ER stress inhibitor. Translational Stroke Research. 2013;4(6):635-42. Epub 2013/12/11. doi: 10.1007/s12975-013-0282-1. PubMed PMID: 24323417; PubMed Central PMCID: PMC3864671. *denotes co-first authorship.


Mohd Azrin bin Jamalruddin

Journal Articles

Brunette GJ, Jamalruddin MA, Baldock RA, Clark NL, Bernstein KA.   Evolution-based screening enables genome-wide prioritization and discovery of DNA repair genes.  Proc Natl Acad Sci U S A. 2019 Sep 24;116(39):19593-19599. doi: 10.1073/pnas.1906559116. Epub 2019 Sep 9. PMID: 31501324  PMCID: PMC6765268
 

Nicole Kaminski

Journal Articles

Hoang SM, Kaminski N, Bhargava R, Barroso-González J, Lynskey ML, García-Expósito L, Roncaioli JL, Wondisford AR, Wallace CT, Watkins SC, James DI, Waddell ID, Ogilvie D, Smith KM, da Veiga Leprevost F, Mellacharevu D, Nesvizhskii AI, Li J, Ray-Gallet D, Sobol RW, Almouzni G, O'Sullivan RJ.  Regulation of ALT-associated homology-directed repair by polyADP-ribosylation. Nat Struct Mol Biol. 2020 Dec;27(12):1152-1164. doi: 10.1038/s41594-020-0512-7. Epub 2020 Oct 12. PMID: 33046907  PMCID: PMC7809635
 
Kaminski, N.A. and Wong, E.A. (2018) Differential mRNA expression of nutrient transporters in male and female chickens. Poultry Science, (97)1: 313–318, https://doi.org/10.3382/ps/pex262
 

Matthew Keeney

Journal Articles

Rocha EM, De Miranda BR, Castro S, Drolet R, Hatcher NG, Yao L, Smith SM, Keeney MT, Di Maio R, Kofler J, Hastings TG, Greenamyre JT.    LRRK2 inhibition prevents endolysosomal deficits seen in human Parkinson's disease.Neurobiol Dis. 2020 Feb;134:104626. doi: 10.1016/j.nbd.2019.104626. Epub 2019 Oct 13. PMID: 31618685 PMCID: PMC7345850
 

Thong Luong

Journal Articles

Baldock RA, Pressimone CA, Baird JM, Khodakov A, Luong TT, Grundy MK, Smith CM, Karpenshif Y, Bratton-Palmer DS, Prakash R, Jasin M, Garcin EB, Gon S, Modesti M, Bernstein KA.  RAD51D splice variants and cancer-associated mutations reveal XRCC2 interaction to be critical for homologous recombination.DNA Repair (Amst). 2019 Apr;76:99-107. doi: 10.1016/j.dnarep.2019.02.008. Epub 2019 Feb 23. PMID: 30836272  PMCID: PMC6508892
 

Egnatchik RA, Brittain EL, Shah AT, Fares WH, Ford HJ, Monahan K, Kang CJ, Kocurek EG, Zhu S, Luong T, Nguyen TT, Hysinger E, Austin ED, Skala MC, Young JD, Roberts LJ 2nd, Hemnes AR, West J, Fessel JP. Dysfunctional BMPR2 signaling drives an abnormal endothelial requirement for glutamine in pulmonary arterial hypertension. Pulm Circ. 2017 Feb 1;7(1):186-199. doi: 10.1086/690236. eCollection 2017 Mar. PubMed PMID: 28680578; PubMed Central PMCID: PMC5448547.

Hardeman KN, Peng C, Paudel BB, Meyer CT, Luong T, Tyson DR, Young JD, Quaranta V, Fessel JP. Dependence On Glycolysis Sensitizes BRAF-mutated Melanomas For Increased Response To Targeted BRAF Inhibition. Sci Rep. 2017 Feb 16;7:42604. doi: 10.1038/srep42604. PubMed PMID: 28205616; PubMed Central PMCID: PMC5311997.


Michelle Lynskey

Journal Articles

Hoang SM, Kaminski N, Bhargava R, Barroso-González J, Lynskey ML, García-Expósito L, Roncaioli JL, Wondisford AR, Wallace CT, Watkins SC, James DI, Waddell ID, Ogilvie D, Smith KM, da Veiga Leprevost F, Mellacharevu D, Nesvizhskii AI, Li J, Ray-Gallet D, Sobol RW, Almouzni G, O'Sullivan RJ.  Regulation of ALT-associated homology-directed repair by polyADP-ribosylation.  Nat Struct Mol Biol. 2020 Dec;27(12):1152-1164. doi: 10.1038/s41594-020-0512-7. Epub 2020 Oct 12. PMID: 33046907  PMCID: PMC7809635
 
Barroso-González J, García-Expósito L, Hoang SM, Lynskey ML, Roncaioli JL, Ghosh A, Wallace CT, de Vitis M, Modesti M, Bernstein KA, Sarkar SN, Watkins SC, O'Sullivan RJ.  RAD51AP1 Is an Essential Mediator of Alternative Lengthening of Telomeres.   Mol Cell. 2019 Oct 3;76(1):11-26.e7. doi: 10.1016/j.molcel.2019.06.043. Epub 2019 Aug 7. PMID: 31400850  PMCID: PMC6778027
 

Sonja Plasil

Journal Articles

Plasil SL, Seth A, Homanics GE.  CRISPR Turbo Accelerated KnockOut (CRISPy TAKO) for Rapid in vivo Screening of Gene Function.  Front Genome Ed. 2020 Oct;2:598522. doi: 10.3389/fgeed.2020.598522. Epub 2020 Oct 21. PMID: 33604589 PMCID: PMC7889042
 
Baratta AM, Rathod RS, Plasil SL, Seth A, Homanics GE.  Exposure to drugs of abuse induce effects that persist across generations.  Int Rev Neurobiol. 2021;156:217-277. doi: 10.1016/bs.irn.2020.08.003. Epub 2020 Sep 30. PMID: 33461664  PMCID: PMC8167819
 
Rathod RS, Ferguson C, Seth A, Baratta AM, Plasil SL, Homanics GE.  Effects of Paternal Preconception Vapor Alcohol Exposure Paradigms on Behavioral Responses in Offspring.   Brain Sci. 2020 Sep 22;10(9):658. doi: 10.3390/brainsci10090658. PMID: 32971974 PMCID: PMC7564629
 

Heidi Schmidt

Journal Articles

Schmidt HM, Wood KC, Lewis SE, Hahn SA, Williams XM, McMahon B, Baust JJ, Yuan S, Bachman TN, Wang Y, Oh JY, Ghosh S, Ofori-Acquah SF, Lebensburger JD, Patel RP, Du J, Vitturi DA, Kelley EE, Straub AC. Xanthine Oxidase Drives Hemolysis and Vascular Malfunction in Sickle Cell Disease.   Arterioscler Thromb Vasc Biol. 2021 Feb;41(2):769-782. doi: 10.1161/ATVBAHA.120.315081. Epub 2020 Dec 3. PMID: 33267657   PMCID: PMC8185582
Kikuchi A, Singh S, Poddar M, Nakao T, Schmidt HM, Gayden JD, Sato T, Arteel GE, Monga SP.  Hepatic Stellate Cell-Specific Platelet-Derived Growth Factor Receptor-α Loss Reduces Fibrosis and Promotes Repair after Hepatocellular Injury.   Am J Pathol. 2020 Oct;190(10):2080-2094. doi: 10.1016/j.ajpath.2020.06.006. Epub 2020 Jun 29. PMID: 32615075  PMCID: PMC7527859
 
Wood KC, Durgin BG, Schmidt HM, Hahn SA, Baust JJ, Bachman T, Vitturi DA, Ghosh S, Ofori-Acquah SF, Mora AL, Gladwin MT, Straub AC.  Smooth muscle cytochrome b5 reductase 3 deficiency accelerates pulmonary hypertension development in sickle cell mice.  Blood Adv. 2019 Dec 10;3(23):4104-4116. doi: 10.1182/bloodadvances.2019000621. PMID: 31821458  PMCID: PMC6963246
Durgin BG, Hahn SA, Schmidt HM, Miller MP, Hafeez N, Mathar I, Freitag D, Sandner P, Straub AC.   Loss of smooth muscle CYB5R3 amplifies angiotensin II-induced hypertension by increasing sGC heme oxidation. JCI Insight. 2019 Oct 3;4(19):e129183. doi: 10.1172/jci.insight.129183. PMID: 31487266  PMCID: PMC6795404
 
Schmidt HM, Kelley EE, Straub AC.   The impact of xanthine oxidase (XO) on hemolytic diseases.  Redox Biol. 2019 Feb;21:101072. doi: 10.1016/j.redox.2018.101072. Epub 2018 Dec 10. PMID: 30580157  PMCID: PMC6305892
 

Regina Schnegelberger

Journal Articles

Lang AL, Goldsmith WT, Schnegelberger RD, Arteel GE, Beier JI.  Vinyl Chloride and High-Fat Diet as a Model of Environment and Obesity Interaction.   J Vis Exp. 2020 Jan 12;(155):10.3791/60351. doi: 10.3791/60351. PMID: 31984951 PMCID: PMC7450540
 
Lang AL, Krueger AM, Schnegelberger RD, Kaelin BR, Rakutt MJ, Chen L, Arteel GE, Beier JI.  Rapamycin attenuates liver injury caused by vinyl chloride metabolite chloroethanol and lipopolysaccharide in mice.  Toxicol Appl Pharmacol. 2019 Nov 1;382:114745. doi: 10.1016/j.taap.2019.114745. Epub 2019 Sep 6. PMID: 31499194  PMCID: PMC6823165
 
Wahlang B, Jin J, Beier JI, Hardesty JE, Daly EF, Schnegelberger RD, Falkner KC, Prough RA, Kirpich IA, Cave MC.   Mechanisms of Environmental Contributions to Fatty Liver Disease.  Curr Environ Health Rep. 2019 Sep;6(3):80-94. doi: 10.1007/s40572-019-00232-w. PMID: 31134516 4  PMCID: PMC6698418
 
Shuboni-Mulligan DD, Parys M, Blanco-Fernandez B, Mallett CL, Schnegelberger R, Takada M, Chakravarty S, Hagenbuch B, Shapiro EM.   Dynamic Contrast-Enhanced MRI of OATP Dysfunction in Diabetes.  Diabetes. 2019 Feb;68(2):271-280. doi: 10.2337/db18-0525. Epub 2018 Nov 28. PMID: 30487262  PMCID: PMC6698418
 
Miki Katuwal, Regina Schnegelberger, Elliott Wityk, Melissa Ruggiero, and Bruno Hagenbuch Establishing the Competitive Counterflow Assay for OATP1B1 and OATP1B3 Published Online:1 Apr 2016Abstract Number:935.5 The FASEB Journal
 

Nicholas Todd

Journal Articles

Huang Y., Todd N., Thathiah A. 2017, The role of GPCRs in neurodegenerative diseases: avenues for therapeutic intervention.  Curr Opin Pharmacol. 2017 Feb;32:96-110. doi: 10.1016/j.coph.2017.02.001. Epub 2017 Mar 10. PMID: 28288370

Anne Wondisford

Journal Articles

Hoang SM, Kaminski N, Bhargava R, Barroso-González J, Lynskey ML, García-Expósito L, Roncaioli
JL, Wondisford AR, Wallace CT, Watkins SC, James DI, Waddell ID, Ogilvie D, Smith KM, da Veiga
Leprevost F, Mellacharevu D, Nesvizhskii AI, Li J, Ray-Gallet D, Sobol RW, Almouzni G, O'Sullivan RJ.
Regulation of ALT-associated homology-directed repair by polyADP-ribosylation. Nat Struct Mol Biol.
2020 Oct 12. doi: 10.1038/s41594-020-0512-7. PMID: 33046907 PMCID: PMC7809635