Skip to Main Content
Pitt Home
Find People
School of Medicine
Toggle navigation
Skip Navigation Links
Home
About
Leadership
Mission
Department Statistics
Building Information
Thomas E. Starzl BST
Biomedical Science Tower 3
Conference Rooms
BSTWR E1347 - Wingard/Lazo Conference Room
BSTWR 1395
Shops
Cell Biology/Pharmacology Machine Shop
Directory
Primary Faculty
Secondary Faculty
Graduate Students
Fellows
Administrative Staff
Research Staff
Adjunct Faculty
Department Alumni
Research
Research Areas
Labs
Equipment
Non-PC&B Personnel Core Facilities Access Request
Funding Opportunities
Faculty Development Program
Responsible Conduct of Research
Education
Molecular Pharmacology Graduate Program
Current Students
Current Student Roster
Student Publications
Diversity, Accessibility, and Counseling
Student Awards
MPGP News
Student Poster and Presentation Resources
Prospective Students
Welcome from the Director
Research Opportunities
PhD Track
MD/PhD Track
Financial Aid
Graduate Faculty
Admin Staff
Graduate Courses
Lab Rotations
Events
Grad Student Event Calendar
Graduate Student Event Schedule
Alumni/Career Development
Alumni
Alumni Contacts
Molecular Pharmacology Facebook Group
Molecular Pharmacology Student-Alumni Network (LinkedIn)
SOM Graduate Studies - Career and Professional Development
Executive Committee
Student Testimonials
IBGP
Funding Opportunities
NIH T32 Training Grant
Outcomes
Predoctoral Fellowship
Admissions
Student Handbook & General Timeline
Links
Useful Links
School of Medicine
PubMed
Remote Resources
Biomedical Masters Program
Undergraduate Research
Summer Fellowships
Lab Rotations
Graduate Fellowships
News
Events
Calendar
Seminar Series
Links
Contact
Opportunities
Department
PORtal
Computer Resources Access Request
IT-Equipment-Facilities Support Request
Poster Requests
Reservation Calendars
Badge Access Request
Home
>
Events
>
Calendar
>
“Structure and functional engineering of the musca...
Pharmacology & Chemical Biology Seminar Series
10/7/2021 - 12:00 PM-1:00 PM
“Structure and functional engineering of the muscarinic receptor toxin”
Shoji Maeda, PhD
Assistant Professor
University of Michigan
Department of Pharmacology
Transmembrane proteins play critical roles in cellular response to the extracellular signals and heir perturbation is responsible for a variety of pathophysiological states. G protein-coupled receptors (GPCRs) is the largest and among the best studied human surface receptor family. Muscarinic acetylcholine receptor (mAChR) family is a prototypical class A GPCR and extensively studied for the subtype selective allosteric modulation of the GPCR due to its conserved orthosteric ligand-binding site. In my talk, I will present our recent data on the structural basis of the strict recognition of mAChR1 by a natural snake toxin and its allosteric regulation. Furthermore, I will provide a promising data to repurpose this natural toxin for more broader use.
Contact
Melanie L Hoffner
412/383-7757