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Recent Student Publications

Wenxi An

Reyes C, An W, Mo L, St Croix C, Shiva S. Nitrite inhibits mitofusin-1 degradation to attenuate vascular smooth muscle proliferation.  In Preparation (to be submitted by July 31, 2021 to Atherosclerosis, Thrombosis and Vascular Biology)

Caitlyn Chapman

Garrudo FFF, Mikael PE, Rodrigues CAV, Udangawa RW, Paradiso P, Chapman CA, Hoffman P, Colaço R, Cabral JMS, Morgado J, Linhardt RJ, Ferreira FC. Polyaniline-polycaprolactone fibers for neural applications: Electroconductivity enhanced by pseudo-doping. Mater Sci Eng C Mater Biol Appl. 2021 Jan;120:111680. doi: 10.1016/j.msec.2020.111680. Epub: 2020 Nov 4
Bhattacharya S, Roy I, Tice A, Chapman C, Udangawa R, Chakrapani V, Plawsky JL, Linhardt RJ. High-Conductivity and High-Capacitance Electrospun Fibers for Supercapacitor Applications. ACS Appl Mater Interfaces. 2020 Apr 29;12(17):19369-19376. doi: 10.1021/acsami.9b21696. Epub: 2020 Apr 20.

Fabliha Chowdhury

Ahmed, T.; Archie, S.R.; Faruk, A.; Chowdhury, F.A.; Shoyaib, A.A.; Ahsan, C.R.Evaluation of the anti-inflammatory activities of diclofenac sodium, prednisolone and atorvastatin in combination with ascorbic acid. Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry. 2020;19(3):291-301. doi: 10.2174/1871523018666190514112048.
Wu L, Li X, Lin Q, Chowdhury F, Mazumder MH, Du W. (2020). FANCD2 and HES1suppress inflammation-induced PPAR? to prevent haematopoietic stem cell exhaustion. Br J Haematol. doi: 10.1111/bjh.17230. PMID: 33222180.
Wu, L.; Lin, Q.; Ma, Z.; Chowdhury, F.A.; Mazumder, M.H.H.; Du, W.Mesenchymal PGD2 activates an ILC2-Treg axis to promote proliferation of normal and malignant HSPCs. Leukemia. 1 November 2020;34(11):3028-3041. doi: 10.1038/s41375-020-0843-8.
Ma, Z.; Xu, J.; Wu, L.; Wang, J.; Lin, Q.; Chowdhury, F.A.; Mazumder, M.H.H.; Hu, G.; Li, X.; Du, W.Hes1 deficiency causes hematopoietic stem cell exhaustion. Stem Cells. 1 June 2020;38(6):756-768. doi: 10.1002/stem.3169.
Lin, Q., Wu, L., Ma, Z., Chowdhury, F. A., Mazumder, H. H., & Du, W. (2020). Persistent DNA damage-induced NLRP12 improves hematopoietic stem cell function. JCI Insight, 5(10). https://doi.org/10.1172/jci.insight.133365. PMID: 32434992.
Wu, L., Lin, Q., Ma, Z., Chowdhury, F. A., Mazumder, M. H. H., & Du, W. (2020). Mesenchymal PGD2 activates an ILC2-Treg axis to promote proliferation of normal and malignant HSPCs. Leukemia. https://doi.org/10.1038/s41375-020-0843-8. PMID: 32366935
Lin, Q.; Wu, L.; Ma, Z.; Chowdhury, F.A.; Mazumder, H.H.; Du, W.Persistent DNA damage-induced NLRP12 improves hematopoietic stem cell function. JCI Insight. May 2020;5(10). doi: 10.1172/JCI.INSIGHT.133365.
Ma, Z., Xu, J., Wu, L., Wang, J., Lin, Q., Chowdhury, F. A., Du, W. (2020). Hes1 deficiency causes hematopoietic stem cell exhaustion. Stem Cells. https://doi.org/10.1002/stem.3169. PMID: 32129527

Kaylee Ermine

Tong J, Tan X, Song X, Gao M, Risnik D, Hao S, Ermine K, Wang P, Li H, Huang Y, Yu J, Zhang L. CDK4/6 Inhibition Suppresses p73 Phosphorylation and Activates DR5 to Potentiate Chemotherapy and Immune Checkpoint Blockade. Cancer Res. 2022 Apr 1;82(7):1340-1352. doi: 10.1158/0008-5472.CAN-21-3062. PMID: 35149588; PMCID: PMC8983601.

Victoria Heinrich

Manni ML, Heinrich VA, Buchan GJ, O’Brien JP, Uvalle C, Cechova V, Koudelka A, Ukani D, Rawas-Qalaji M, Oury TD, Hart R, Ellgass M, Mullet SJ, Fajt ML, Wenzel SE, Holguin F, Freeman BA, Wendell SG. Nitroalkene fatty acids modulate bile acid metabolism and lung function in obese asthma. Eur Respir J. Submitted, under review.
Heinrich VA, Manni ML, Morris A, Wendell SG. Microbial-derived, systemic mediators and lung pathophysiology in obesity-associated asthma. Review in preparation.

Lisa Hong

Lin CC, Mabe NW, Lin YT, Yang WH, Tang X, Hong L, Sun T, Force J, Marks JR, Yao TP, Alvarez JV, Chi JT.  RIPK3 upregulation confers robust proliferation and collateral cystine-dependence on breast cancer recurrence. Cell Death Differ. 2020 Jul;27(7):2234-2247. doi: 10.1038/s41418-020-0499-y. Epub 2020 Jan 27. PMID: 31988496
Lin CC, Mabe NW, Lin YT, Yang WH, Tang X, Hong L, Sun T, Force J, Marks JR, Yao TP, Alvarez JV, Chi JT. RIPK3 upregulation confers robust proliferation and collateral cystine-dependence on breast cancer recurrence. Cell Death Differ. 2020 Jul;27(7):2234-2247. doi: 10.1038/s41418-020-0499-y. Epub 2020 Jan 27.

Matthew Keeney

Keeney MT, Hoffman EK, Farmer K, Bodle CR, Fazzari M, Zharikov A, Castro SL, Hu X, Mortimer A, Kofler JK, Cifuentes-Pagano E, Pagano PJ, Burton EA, Hastings TG, Greenamyre JT, Di Maio R. NADPH oxidase 2 activity in Parkinson's disease. Neurobiol Dis. 2022 Aug;170:105754. doi: 10.1016/j.nbd.2022.105754. Epub 2022 May 13. PMID: 35577065; PMCID: PMC9284948.
Hallacli E, Kayatekin C, Nazeen S, Wang XH, Sheinkopf Z, Sathyakumar S, Sarkar S, Jiang X, Dong X, Di Maio R, Wang W, Keeney MT, Felsky D, Sandoe J, Vahdatshoar A, Udeshi ND, Mani DR, Carr SA, Lindquist S, De Jager PL, Bartel DP, Myers CL, Greenamyre JT, Feany MB, Sunyaev SR, Chung CY, Khurana V. The Parkinson's disease protein alpha-synuclein is a modulator of processing bodies and mRNA stability. Cell. 2022 Jun 09;185(12):2035-2056.e33. pii: S0092-8674(22)00592-X.
Keeney MT, Hoffman EK, Farmer K, Bodle CR, Fazzari M, Zharikov A, Castro SL, Hu X, Mortimer A, Kofler JK, Cifuentes-Pagano E, Pagano PJ, Burton EA, Hastings TG, Greenamyre JT, Di Maio R. NADPH oxidase 2 activity in Parkinson's disease. Neurobiol Dis. 2022 Aug;170:105754. pii: S0969-9961(22)00146-2. Epub 2022 May 13.
Rocha EM, Keeney MT, Di Maio R, De Miranda BR, Greenamyre JT. LRRK2 and idiopathic Parkinson's disease. Trends Neurosci. 2022 Mar;45(3):224-236. pii: S0166-2236(21)00250-2. Epub 2022 Jan 04.

Michelle Lynskey

Hoang, S.M.; Kaminski, N.; Bhargava, R.; Barroso-González, J.; Lynskey, M.L.; García-Expósito, L.; Roncaioli, J.L.; Wondisford, A.R.; Wallace, C.T.; Watkins, S.C.; James, D.I.; Waddell, I.D.; Ogilvie, D.; Smith, K.M.; da Veiga Leprevost, F.; Mellacharevu, D.; Nesvizhskii, A.I.; Li, J.; Ray-Gallet, D.; Sobol, R.W.; Almouzni, G.; O’Sullivan, R.J.Regulation of ALT-associated homology-directed repair by polyADP-ribosylation. Nature Structural and Molecular Biology. December 2020;27(12):1152-1164. doi: 10.1038/s41594-020-0512-7. 
Hoang SM, Kaminski N, Bhargava R, Barroso-González J, Lynskey ML, García-Expósito L, Roncaioli JL, Wondisford AR, Wallace CT, Watkins SC, James DI, Waddell ID, Ogilvie D, Smith KM, da Veiga Leprevost F, Mellacharevu D, Nesvizhskii AI, Li J, Ray-Gallet D, Sobol RW, Almouzni G, O'Sullivan RJ.  Regulation of ALT-associated homology-directed repair by polyADP-ribosylation.  Nat Struct Mol Biol. 2020 Dec;27(12):1152-1164. doi: 10.1038/s41594-020-0512-7. Epub 2020 Oct 12. PMID: 33046907  PMCID: PMC7809635
 

Bellina Mushala

Thapa D, Xie B, Mushala BAS, Zhang M, Manning JR, Bugga P, Stoner MW, Jurczak MJ, Scott I. Diet-induced obese mice are resistant to improvements in cardiac function resulting from short-term adropin treatment. Curr Res Physiol. 2022 Jan 25;5:55-62. doi: 10.1016/j.crphys.2022.01.005. PMID: 35128468; PMCID: PMC8803554.
Thapa D, Bugga P, Mushala BAS, Manning JR, Stoner MW, McMahon B, Zeng X, Cantrell PS, Yates N, Xie B, Edmunds LR, Jurczak MJ, Scott I. GCN5L1 impairs diastolic function in mice exposed to a high fat diet by restricting cardiac pyruvate oxidation. Physiol Rep. 2022 Aug;10(15):e15415. doi: 10.14814/phy2.15415. PMID: 35924321; PMCID: PMC9350469.

Sonja Plasil

Plasil SL, Seth A, Homanics GE.  CRISPR Turbo Accelerated KnockOut (CRISPy TAKO) for Rapid in vivo Screening of Gene Function.  Front Genome Ed. 2020 Oct;2:598522. doi: 10.3389/fgeed.2020.598522. Epub 2020 Oct 21. PMID: 33604589 PMCID: PMC7889042
 
Plasil SL, Seth A, Homanics GE. CRISPR Turbo Accelerated KnockOut (CRISPy TAKO) for Rapid in vivo Screening of Gene Function. Front Genome Ed. 2020 Oct;2. pii: 598522. Epub 2020 Oct 21.
Baratta AM, Rathod RS, Plasil SL, Seth A, Homanics GE.  Exposure to drugs of abuse induce effects that persist across generations.  Int Rev Neurobiol. 2021;156:217-277. doi: 10.1016/bs.irn.2020.08.003. Epub 2020 Sep 30. PMID: 33461664  PMCID: PMC8167819
 
Rathod RS, Ferguson C, Seth A, Baratta AM, Plasil SL, Homanics GE.  Effects of Paternal Preconception Vapor Alcohol Exposure Paradigms on Behavioral Responses in Offspring.   Brain Sci. 2020 Sep 22;10(9):658. doi: 10.3390/brainsci10090658. PMID: 32971974 PMCID: PMC7564629
 
Rathod RS, Ferguson C, Seth A, Baratta AM, Plasil SL, Homanics GE. Effects of Paternal Preconception Vapor Alcohol Exposure Paradigms on Behavioral Responses in Offspring. Brain Sci. 2020 Sep 22;10(9) . pii: E658. Epub 2020 Sep 22.

Sripriya Raja

Kumar, N.; Raja, S.; Van Houten, B.The involvement of nucleotide excision repair proteins in the removal of oxidative DNA damage. Nucleic Acids Research. 18 November 2020;48(20):11227-11243. doi: 10.1093/nar/gkaa777.
Kumar N*, Raja S*, Van Houten B. The involvement of nucleotide excision repair proteins in the removal of oxidative DNA damage [published online ahead of print, 2020 Oct 3]. Nucleic Acids Res. 2020;gkaa777. doi:10.1093/nar/gkaa777

Hayley Rein

Prakash R, Sandoval T, Morati F, Zagelbaum JA, Lim PX, White T, Taylor B, Wang R, Desclos ECB, Sullivan MR, Rein HL, Bernstein KA, Krawczyk PM, Gautier J, Modesti M, Vanoli F, Jasin M. Distinct pathways of homologous recombination controlled by the SWS1-SWSAP1-SPIDR complex. Nat Commun. 2021 Jul 12;12(1):4255. doi: 10.1038/s41467-021-24205-6. Epub 2021 Jul 12.
Rein, H., Bernstein, K., Baldock, R. (2021), RAD51 paralog function in replicative DNA damage and tolerance, Current Opinions in Genetics and Development, Accepted.
Prakash R, Rawal Y, Sullivan MR, Grundy MK, Bret H, Mihalevic MJ, Rein HL, Baird JM, Darrah K, Zhang F, Wang R, Traina TA, Radke MR, Kaufmann SH, Swisher EM, Guérois R, Modesti M, Sung P, Jasin M, Bernstein KA. Homologous recombination-deficient mutation cluster in tumor suppressor RAD51C identified by comprehensive analysis of cancer variants. Proc Natl Acad Sci U S A. 2022 Sep 20;119(38):e2202727119. doi: 10.1073/pnas.2202727119. Epub 2022 Sep 13.
Jiang, Z., Lai, Y., Beaver, J., Tsegay, P., Zhao, M., Horton, J., Zamora,M., Rein, H., Mirales, F., Shaver, M., Hutcheson, J., Agoulnik I., Wilson, S. and Liu, Y. 2020. Oxidative DNA Damage Modulates DNA Methylation Pattern in Human Breast Cancer 1 (BRCA1) Gene via the Crosstalk between DNA Polymerase β and a de novo DNA Methyltransferase. Cells. 9(1):225
Jiang, Z.; Lai, Y.; Beaver, J.M.; Tsegay, P.S.; Zhao, M.-L.; Horton, J.K.; Zamora, M.; Rein, H.L.; Miralles, F.; Shaver, M.; Hutcheson, J.D.; Agoulnik, I.; Wilson, S.H.; Liu, Y.Oxidative DNA Damage Modulates DNA Methylation Pattern in Human Breast Cancer 1 (BRCA1) Gene via the Crosstalk between DNA Polymerase ß and a de novo DNA Methyltransferase. Cells. 16 January 2020;9(1). doi: 10.3390/cells9010225.

Sofya Savransky

Langowski MD, Khan FA, Savransky S, Brown DR, Balasubramaniyam A, Harrison WB, Zou X, Beck Z, Matyas GR, Regules JA, Miller R, Soisson LA, Batchelor AH, Dutta S. Restricted valency (NPNA)n repeats and junctional epitope-based circumsporozoite protein vaccines against Plasmodium falciparum. NPJ Vaccines. 2022 Jan 27;7(1):13. doi: 10.1038/s41541-022-00430-y. Epub 2022 Jan 27.

Heidi Schmidt

Schmidt HM, Wood KC, Lewis SE, Hahn SA, Williams XM, McMahon B, Baust JJ, Yuan S, Bachman TN, Wang Y, Oh JY, Ghosh S, Ofori-Acquah SF, Lebensburger JD, Patel RP, Du J, Vitturi DA, Kelley EE, Straub AC. Xanthine Oxidase Drives Hemolysis and Vascular Malfunction in Sickle Cell Disease.   Arterioscler Thromb Vasc Biol. 2021 Feb;41(2):769-782. doi: 10.1161/ATVBAHA.120.315081. Epub 2020 Dec 3. PMID: 33267657   PMCID: PMC8185582
Kikuchi A, Singh S, Poddar M, Nakao T, Schmidt HM, Gayden JD, Sato T, Arteel GE, Monga SP.  Hepatic Stellate Cell-Specific Platelet-Derived Growth Factor Receptor-α Loss Reduces Fibrosis and Promotes Repair after Hepatocellular Injury.   Am J Pathol. 2020 Oct;190(10):2080-2094. doi: 10.1016/j.ajpath.2020.06.006. Epub 2020 Jun 29. PMID: 32615075  PMCID: PMC7527859
 
Kikuchi, A., Singh, S., Poddar, M., Nakao, T., Schmidt, H.M., Gayden, J.D., Sato, T., Arteel, G.E., Monga, S.P., “Hepatic stellate cell-specific platelet-derived growth factor receptor α loss reduces fibrosis and promotes repair following hepatocellular injury,” The American Journal of Pathology. doi: 10.1016/j.ajpath.2020.06.006. (2020)
 

Anne Wondisford

Hoang SM, Kaminski N, Bhargava R, Barroso-González J, Lynskey ML, García-Expósito L, Roncaioli JL, Wondisford AR, Wallace CT, Watkins SC, James DI, Waddell ID, Ogilvie D, Smith KM, da Veiga Leprevost F, Mellacharevu D, Nesvizhskii AI, Li J, Ray-Gallet D, Sobol RW, Almouzni G, O'Sullivan RJ. Regulation of ALT-associated homology-directed repair by polyADP-ribosylation. Nat Struct Mol Biol. 2020 Dec;27(12) :1152-1164. doi: 10.1038/s41594-020-0512-7. Epub 2020 Oct 12.
Hoang, S.M.; Kaminski, N.; Bhargava, R.; Barroso-González, J.; Lynskey, M.L.; García-Expósito, L.; Roncaioli, J.L.; Wondisford, A.R.; Wallace, C.T.; Watkins, S.C.; James, D.I.; Waddell, I.D.; Ogilvie, D.; Smith, K.M.; da Veiga Leprevost, F.; Mellacharevu, D.; Nesvizhskii, A.I.; Li, J.; Ray-Gallet, D.; Sobol, R.W.; Almouzni, G.; O’Sullivan, R.J.Regulation of ALT-associated homology-directed repair by polyADP-ribosylation. Nature Structural and Molecular Biology. December 2020;27(12):1152-1164. doi: 10.1038/s41594-020-0512-7. 
Hoang SM, Kaminski N, Bhargava R, Barroso-González J, Lynskey ML, García-Expósito L, Roncaioli
JL, Wondisford AR, Wallace CT, Watkins SC, James DI, Waddell ID, Ogilvie D, Smith KM, da Veiga
Leprevost F, Mellacharevu D, Nesvizhskii AI, Li J, Ray-Gallet D, Sobol RW, Almouzni G, O'Sullivan RJ.
Regulation of ALT-associated homology-directed repair by polyADP-ribosylation. Nat Struct Mol Biol.
2020 Oct 12. doi: 10.1038/s41594-020-0512-7. PMID: 33046907 PMCID: PMC7809635