I am interested in how neuropeptide signaling regulates adaptive behaviors and how these signaling pathways cope with stressful changes in their environment. I use leading-edge techniques to monitor the traffic of neuropeptides to nerve terminals, their subsequent release, and their effects on post-synaptic signaling in clock circuit neurons. I am currently creating a 4-D map of neuropeptide release in the clock circuit to determine (a) when and where important neuropeptides are being released, (b) how this timing is altered during sleep deprivation, Jet Lag and during seasonal changes in light patterns, and (c) how the timing of these daily rhythms are regulated at the cellular and circuit level to control rhythmic behaviors.