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“Dynamic regulation of microglia metabolism and fu...
Pharmacology & Chemical Biology Seminar Series
4/7/2022 - 12:00 PM-1:00 PM
“Dynamic regulation of microglia metabolism and function in CNS injury and repair”
Dandan Sun, MD, PhD
Professor, Department of Neurology
UPMC Endowed Chair Professor of Brain Disorders Research
University of Pittsburgh School of Medicine
The balance between glycolysis and OXPHOS is important for the transition between the damaging immune responses and their restorative functions in many immune cells. Therefore, immune dysfunction/dysregulation is closely associated with loss of balance in immune energy metabolism homeostasis in many diseases, such as cancer, Alzheimer’s disease, stroke, etc. This seminar will discuss our research on modulating
a key pH regulator Na/H exchanger (NHE1) function in stimulating microglial OXPHOS metabolism and phagocytosis functions in stroke brain repair. In addition, I will also discuss our recent study that blockade of
NHE1 protein improved glioma tumor immunity and OXPHOS function of myeloid cells in experimental glioma models.
Contact
Melanie L Hoffner