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Pharmacology & Chemical Biology
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Cancer Pharmacology
Cardiovascular and Renal Pharmacology
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Neuropharmacology
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Signal Transduction
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Tija C. Jacob, PhD
Director, Molecular Pharmacology Graduate Program
Research Info
GABA A receptor neuropharmacology and synapses, inhibition, neurodevelopment, mental health disorders.
Patrick J. Pagano, PhD
Professor
Associate Director, Molecular Pharmacology Graduate Program
Program Director, Predoctoral Training in Pharmacological Sciences
Research Info
Development of peptic, viral and small molecular inhibitors of NADPH oxidases and reactive species to assess NOX involvement in cardiovascular disease as well as to devise new therapies
Guillermo G. Romero, PhD
Associate Professor
Associate Director, Molecular Pharmacology Graduate Program
Research Info
Regulation of G-protein coupled receptor function by phospholipase D and PDZ proteins; molecular regulation of Wnt signaling. Signal Transduction mechanisms associated to the activation of cellular phospholipases.
Jinwoo Ahn, PhD
Department of Structural Biology
Research Info
Dr. Ahn’s laboratory investigates the molecular and structural basis of HIV protein and host DNA repair protein interactions during early states of HIV cellular infection by using various bioanalytical and biophysical methods including CD, fluorescen...
Katherine Aird, PhD
Associate Professor
Elias Aizenman, PhD
Department of Neurobiology
Research Info
Cellular and molecular mechanisms of neuronal cell death
Imad Al Ghouleh, PhD
Department of Medicine Division Cardiology
Jonathan K. Alder, PhD
Department of Medicine Division Pulmonary, Allergy and Critical Care Medicine
Daniel Altschuler, PhD
Department of Pharmacology & Chemical Biology
Research Info
G-protein signaling mechanisms in mitogenesis and oncogenesis
Gavin E. Arteel, PhD, FAASLD
Department of Medicine Division Gastroenterology
Christopher Bakkenist, PhD
Department of Radiation Oncology
Research Info
DNA damage signaling
Aaron Barchowsky, PhD
Department of Environmental and Occupational Health
Research Info
The main focus of the research in the Barchowsky laboratory is the cellular and molecular mechanisms for pathogenic tissue remodeling and metabolic dysfunction caused by environmental metals exposures. The core theme of the research has been on meta...
Hülya Bayir, MD
Department of Critical Care Medicine
Research Info
Dr. Hülya Bayir’s research focuses on the primary themes of mitochondrial injury and oxidative signaling. She has organized a multidisciplinary team of investigators to study novel approaches to the treatment of mitochondrial dysfunction by targeting...
Juliane I. Beier , PhD
Department of Medicine Division Gastroenterology
Kara Bernstein, PhD
Associate Professor
Robert Binder, PhD
Department of Immunology
Research Info
Tumor immunology; Heat Shock Protein Immunobiology; Tumor immunosurveillance; biology of scavenger receptors in antigen crosspresentation; immune responses initiated by endogenous molecules.
Lori A. Birder, PhD
Department of Medicine Division Renal-Electrolyte
Research Info
Study a number of ion channel/receptor targets within the bladder epithelium and the possible role of the urothelium in urinary bladder function.
Dr. Alessandro Bisello
Department of Pharmacology & Chemical Biology
Research Info
Structure, signalling and trafficking of G-protein-coupled receptors. Role of EBP50 in vascular remodeling and role of GLP-1 in pancreatic beata cell function.
Thiago Bruder do Nascimento, PhD
Assistant Professor of Pediatrics
Timothy F. Burns, MD, PhD
Department of Medicine Division of Hematology/Oncology
Research Info
Targeted therapies for lung cancer; KRAS mutant lung cancer; Hsp90 inhibitors;EMT transcription factors
Stephen Chan, MD, PhD
Department of Medicine Division Cardiology
Research Info
We are a basic science and translational research group studying the molecular mechanisms of pulmonary vascular disease and pulmonary hypertension (PH) – an example of an enigmatic disease where reductionistic studies have primarily focused on end-st...
Yuanyuan Chen, PhD
Department of Ophthalmology
Donald B. DeFranco, PhD
Department of Pharmacology & Chemical Biology
Research Info
Glucocorticoids and Neurodevelopment. Prostate cancer.
Wei Du, MD, PhD
Associate Professor
John Fernstrom, PhD
Department of Psychiatry
Research Info
Control of neurotransmitter and neuropeptide synthesis and function.
Bruce A. Freeman, PhD
Department of Pharmacology & Chemical Biology
Research Info
Cell Signaling; Redox Reactions
Peter A. Friedman, PhD
Department of Pharmacology & Chemical Biology
Research Info
Parathyroid hormone receptor trafficking, regulation, signaling.
Ferruccio Galbiati, PhD
Department of Pharmacology & Chemical Biology
Research Info
Signal transduction mechanisms in muscular dystrophy and ageing/cancer.
Mark T. Gladwin, MD
Department of Medicine Division Pulmonary, Allergy and Critical Care Medicine
Research Info
Dr. Gladwin's clinical research and expertise focuses on pulmonary hypertension and pulmonary complications of sickle cell disease.
J. Timothy Greenamyre, MD, PhD
Department of Neurology
Angela M. Gronenborn, PhD
Department of Structural Biology
Research Info
Biomolecular structure and its correlation to function in transcription factor compleses, HIV-2 proteins and signaling proteins.
Aditi Gurkar, PhD
Department of Medicine Division Geriatrics
Gregg E. Homanics, PhD
Department of Anesthesiology and Perioperative Medicine
Research Info
Application of transgenic technologies to investigate the molecular targets of ethanol and general anesthetics; production of animal models of human disease
John P. Horn, PhD
Department of Neurobiology
Research Info
Synaptic integration in sympathetic ganglia and in midbrain dopamine neurons; neurotransmitter signaling through G-protein coupled receptors
Edwin K. Jackson, PhD
Department of Pharmacology & Chemical Biology
Research Info
The physiology and pharmacology of endogenous modulators of growth, structure and function of cells in the heart, blood vessels and kidneys, with particular focus on adenosine, the renin-angiotensin soystem and estradiol metabolites.
Yu Jiang, PhD
Department of Pharmacology & Chemical Biology
Research Info
Signaling mechanisms for cell growth control; Regulation of protein kinases and phosphatases
Michael J. Jurczak, PhD
Department of Medicine Division Endocrinology and Metabolism
Valerian Kagan, PhD
Department Environmental and Occupational Health
Research Info
Nitric oxide interactions with cellular components, redox status during cellular injury and repair
Anthony Kanai, PhD
Department of Medicine Division Renal-Electrolyte
Research Info
Roles of the urothelium, interstitial cells and afferent nerves in urinary incontinence--studied using optical mapping. Nitric oxide in radiation cystitis and the mitochondrial targeting of radioprotectants.
Lawrence P. Kane, PhD
Department of Immunology
Research Info
The role of the Akt kinase in T cell activation; Immunilogic function and signaling of TIM proteins
Seungwon Kim, MD
Department of Otolaryngology
Research Info
Advanced skin cancer, oral cancer, thyroid cancer and targeted therapy for head and neck cancer.
Thomas R. Kleyman, MD
Department of Medicine Division Renal-Electrolyte Physiology, Chief, Renal-Electrolyte Division
Adrian Lee, PhD
Department of Pharmacology & Chemical Biology
Edwin S. Levitan, PhD
Department of Pharmacology & Chemical Biology
Research Info
Neurotransmission, channels and signaling.
Michael T. Lotze, MD
Department of Immunology
Research Info
Tumor immunology; dendritic cell biology; cytokine biology; regulation of apoptosis in immune effectors; role of the nuclear protein HMGB 1 in promoting inflammation, mRNA role in regulating the translation of proteins in macrophages and other inflam...
Ana L. Mora, MD
Department of Medicine Division Pulmonary, Allergy and Critical Care Medicine
Alison Morris, MD, MS
Department of Medicine Division Pulmonary, Allergy and Critical Care Medicine
Yael Nechemia-Arbely, PhD
Assistant Professor
Research Info
Research in the lab is focused on understanding the structure, composition and maintenance of the epigenetically defined human centromeres.
Carola Neumann, MD
Department of Pharmacology & Chemical Biology
Enrico M Novelli, MD
Department of Medicine Division Hematology/Oncology
Roderick J. O'Sullivan, PhD
Department of Pharmacology & Chemical Biology
Research Info
Study of the consequences that defective chromatin assembly and altered epigenetic mechanisms may have in cancer and aging.
Steffi Oesterreich, PhD
Department of Pharmacology & Chemical Biology
Research Info
Molecular mechanism and clinical relevance of endocrine response in breast cancer
Michael J. Palladino, PhD
Department of Pharmacology & Chemical Biology
Research Info
Combined molecular and genetic approach to identify key proteins required for neural maintenance with age and understand the role of these gene products in human disease conditions.
Francisco J. Schopfer, PhD
Associate Professor
Iain Scott, PhD
Department of Medicine Division Cardiology
Research Info
The general focus of my laboratory is mitochondrial metabolism and bioenergetics, and the role that mitochondrial dysfunction can play in the pathophysiology of human diseases.
Yi Shi, PhD
Assistant Professor, Department of Cell Biology
Sruti Shiva, PhD
Department of Pharmacology & Chemical Biology
Research Info
The mechanisms by which reactive nitrogen species regulate mitochondrial function and signaling, particularly in conditions of hypoxia or ischemia.
Shivendra Singh, PhD
Department of Pharmacology & Chemical Biology
Research Info
The Singh laboratory focuses on preclinical and clinical investigations of novel agents derived from dietary (eg, broccoli) and medicinal plants (eg, Withania somnifera) for chemoprevention of cancers.
Thomas E. Smithgall, PhD
Department of Microbiology and Molecular Genetics
Research Info
Protein-tyrosine kinase structure, function, and drug discovery in cancer and infectious diseases.
Richard Steinman, MD
Department of Medicine Division Hematology/Oncology
Research Info
Molecular controls of normal hematopoiesis and leukemogenisis; coupling of cell cycle and differentation control. Investigation of p-53 like molecules and cell cycle regulation in leukemogenesis and in stem cells.
Adam C. Straub, PhD
Department of Pharmacology & Chemical Biology
Research Info
Redox signaling mechanisms in the microcirculation.
Pei Tang, PhD
Department of Anesthesiology and Perioperative Medicine
Research Info
Structural biology/computational biology/protein drug interactions/molecular mechanism of general anesthesia.
Jesus Tejero Bravo
Associate Professor
Amantha Thathiah, PhD
Department of Neurobiology
Mary M. Torregrossa, PhD
Department of Psychiatry
Thanos Tzounopoulos, PhD
Department of Otolaryngology
Research Info
Cellular mechanisms for learning and memory and their role in auditory processing.
Ben Van Houten, PhD
Department of Pharmacology & Chemical Biology
Research Info
Mitochondrial dysfunction in cancer and neurodegenerative diseases , structure function of DNA repair enzymes/proteins.
Jean-Pierre Vilardaga, PhD
Department of Pharmacology & Chemical Biology
Research Info
Understanding molecular mechanisms of G protein-coupled receptor(GPCR) signalling and trafficking.
Man-Tzu Wang, PhD
Assistant Professor
Qiming Jane Wang, PhD
Department of Pharmacology & Chemical Biology
Research Info
Targeting protein kinase D by small molecular inhibitors for cancer therapy; signaling mechanisms of protein kinase D in cancer.
Zhou Wang, PhD
Department of Urology
Research Info
Mechanism of androgen receptor intracellular trafficking in prostate cancer cells. Roles of androgen-response genes in prostate cancer and benign prostatic hyperplasia.
Peter Wipf, PhD
Department of Chemistry
Research Info
Medicinal chemistry and drug design. Total synthesis of natural products.
Wen Xie, MD, PhD
Department of Pharmaceutical Sciences
Research Info
Nuclear hormone receptor-mediated gene regulation in endrocrinology, gastroenterology, and cancer. Nuclear hormone receptors as therapeutic targets for metabolic syndrome.
Yan Xu, PhD
Department of Anesthesiology and Perioperative Medicine
Research Info
Gene and stem cell therapy in brain ischemia membrane protein structure by NMR; biological basis of unconsciousness; molecular mechanisms of general anesthesia.
Cheng Zhang, PhD
Department of Pharmacology & Chemical Biology
Research Info
Structural basis for G protein-coupled receptor (GPCR) signaling; development of GPCR antibodies through protein engineering.
Lin Zhang, PhD
Department of Pharmacology & Chemical Biology
Research Info
Genetic basis of differential responses to anticancer drugs and mechanisms of drug-induced apoptosis.