William C. de Groat, PhD

Distinguished Professor

W 1352 Thomas E. Starzl Biomedical Science Tower
Pittsburgh, PA 15261
Phone: 412-648-9357
Fax: 412-648-1945

Education

BS (Pharmacy), Philadelphia College of Pharmacy and Science, 1960
MS (Pharmacology), Philadelphia College of Pharmacy and Science, 1962
PhD (Pharmacology), University of Pennsylvania Medical School, 1965
Postdoctoral Fellow, University of Pennsylvania Medical School, 1965-1966.
Postdoctoral Fellow, Australian National University, Dept. of Physiology, 1966-1968
William C. de Groat, PhD

Dr. de Groat is interested in the autonomic nervous system and the neural regulation of pelvic visceral functions. Current studies focus on the reflex control of the urogenital tract and the mechanisms underlying transmission at central and peripheral autonomic synapses. These experiments are designed to examine (1) the neurotransmitters in the reflex pathways, (2) neuroplasticity during postnatal development or following neural injury, (3) the neural pathways responsible for the detection of visceral pain, and (4) the actions of drugs used to treat urogenital dysfunction. Experiments are conducted on a variety of preparations ranging from intact animals to isolated tissues, like spinal cord slices and dissociated neurons.

de Groat WC and C Wickens.  Organization of the neural switching circuitry underlying reflex micturition.  Acta Physiologica 207:66-84, 2013.
Fitzgerald J, E Ustinova, K Koronowski, WC de Groat and M Pezzone.  Evidence for the role of mast cells in bowel-bladder cross organ sensitization.  Autonomic Neuroscience Basic and Clinical 173:6-13, 2013.
Yu Y and WC de Groat.  Nitric oxide modulates bladder afferent nerve activity in the in vitro urinary bladder-pelvic preparation from rats with cyclophosphamide induced cystitis.  Brain Research 1490:83-94, 2013.
Mally AD, Y Matsuta, F Zhang, B Shen, J Wang, JR Roppolo, WC de Groat and C Tai.  Role of opioid and metabotropic glutamate 5 receptors in pudendal inhibition of bladder overactivity in cats.  Journal of Urology 189:1574-1579, 2013.
Tai C, JA Larson, PD Ogagan, G Chen, B Shen, J Wang, JR Roppolo and WC de Groat.  Differential role of opioid receptors in tibial nerve inhibition of nociceptive and non-nociceptive bladder reflexes in cats.  American Journal of Renal Physiology 302:F1090-F1097, 2012.
Zhang X, C Pietra, E Lovati and WC de Groat.  Activation of neurokinin-1 receptors increases the excitability of guinea pig dorsal root ganglion cells.  Journal of Pharmacology and Experimental Therapeutics 343:44-52, 2012.
Tai C, B Shen, AD Mally, F Zhang, J Wang, JR Roppolo and WC de Groat.  Inhibition of micturition reflex by activation of somatic afferents in posterior femoral cutaneous nerve.  Journal of Physiology (London) 590:4945-4955, 2012.

Sponsored Research

Underlying mechanisms controlling urothelial ATP release and their contributions to urinary bladder physiology and pathophysiology - 8/20/2018 - 5/31/2023
NIH - R01 DK117884
RELIEPH for Interstitial Cystitis - 7/1/2018 - 3/31/2023
NIH - R01DK117383
Coordinated Microstimulation of Sacral Afferent Pathways to Control Continence and Micturition Reflexes - 4/1/2017 - 3/31/2022
NIH - R01NS088184
Parasympathetic and sympathetic mechanisms underlying bladder nociception - 1/11/2017 - 12/31/2020
NIH - R01DK111382
PDE5 Inhibition of afferents and Interstitial Cells in Overactive Mouse Bladders - 9/20/2014 - 8/31/2019
NIH - R01DK098361