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Pharmacology and Chemical Biology Seminar Series

Pharmacology & Chemical Biology Seminar Series
12/15/2022 - 12:00 PM-1:00 PM

Mikel Garcia-Marcos, PhD 
Professor
Department of Biochemistry
Boston University School of Medicine
 

Our research program aims to understand the mechanisms and consequences cell communication via heterotrimeric G-proteins (Gαβγ) because they represent major intracellular hubs of signaling with very direct biomedical relevance. To achieve this goal, we use a wide range of approaches (biochemistry, cell biology, genetics, drug screening/ development) and experimental systems (purified proteins, cultured cells, model organisms) in combination with the development of novel tools (biosensors, chemogenetics, optogenetics). Our ongoing efforts have direct implications in cancer, embryonic development defects, and neurological disorders.

 
 

Pharmacology & Chemical Biology Seminar Series
1/12/2023 - 12:00 PM-1:00 PM

Delphine Gomez, PhD 
Assistant Professor of Medicine
Department of Medicine, Division of Cardiology
Heart, Lung and Blood VMI
University of Pittsburgh

Dr. Gomez studies the role of epigenetic and transcriptional mechanisms controlling fundamental properties of vascular smooth muscle cells. Using multi-scale omics and epigenome editing approaches, her laboratory investigates the causal relationship between the establishment of lineage-specific chromatin or non-coding RNA signatures and the maintenance of vascular cell identity and functions.
 

Pharmacology & Chemical Biology Seminar Series
1/19/2023 - 12:00 PM-1:00 PM

Oliver Eickelberg, MD, FERS, ATSF 
Professor of Medicine
University of Pittsburgh


Pharmacology & Chemical Biology Seminar Series
1/26/2023 - 12:00 PM-1:00 PM

Anna Martner, PhD 
Sahlgrenska Center for Cancer Reserach
University of Gothenburg

**VIRTUAL SEMINAR**

Pharmacology & Chemical Biology Seminar Series
2/2/2023 - 12:00 PM-1:00 PM

Stephen Meriney, PhD 
Professor and Chair, Neuroscience
University of Pittsburgh

My talk will focus on the rational design and development of a novel voltage-gated calcium channel drug.  I will start with the basic science that led to the discovery, and then present the pre-clinical data that supports the development of this drug for use in a variety of neuromuscular diseases (including SMA, ALS, and LEMS), as well as frailty in normal aging.    
 

Pharmacology & Chemical Biology Seminar Series
2/9/2023 - 12:00 PM-1:00 PM

Abby Olsen, MD, PhD 
Assistant Professor Neurology
University of Pittsburgh

There are no disease-modifying therapies for Parkinson’s disease, and glial cells have been overlooked as a source of potential therapeutic targets. Dr. Olsen will discuss efforts to better understand the genetic contribution of glia to Parkinson’s disease pathogenesis. These efforts rely heavily on a Drosophila model of Parkinson’s disease that can be used to understand the mechanism of known risk genes in glia and also to identify novel glial genes that contribute to pathogenesis. 
 

Pharmacology & Chemical Biology Seminar Series
2/16/2023 - 12:00 PM-1:00 PM

Christian Fernandez, PhD 
Associate Professor
Department of Pharmaceutical Sciences
University of Pittsburgh

The immunotoxicity of protein-based therapeutics, such as to asparaginase and the tumor necrosis factor α (TNFα) inhibitor adalimumab, is a major problem that influences drug efficacy. Our research integrates clinical pharmacogenomic approaches and experimental validations using genetic and pharmacological models to elucidate the underlying molecular mechanisms of immunotoxicity and to identify therapeutic strategies for protecting against the drug-induced toxicity.

Pharmacology & Chemical Biology Seminar Series
2/23/2023 - 12:00 PM-1:00 PM

Osama Harraz, PhD 
Assistant Professor
Department of Pharmacology
Larner College of Medicine
University of Vermont


Pharmacology & Chemical Biology Seminar Series
3/2/2023 - 12:00 PM-1:00 PM

Wayne Stallaert, PhD 
Assistant Professor
Department of Computational and Systems Biology
Hillman Cancer Center
University of Pittsburgh


Pharmacology & Chemical Biology Seminar Series
3/16/2023 - 12:00 PM-1:00 PM

Murali Prakriya, PhD 
Magerstadt Professor
Department of Pharmacology
Department of Medicine
Feinberg School of Medicine
Northwestern University


Pharmacology & Chemical Biology Seminar Series
3/23/2023 - 12:00 PM-1:00 PM

Melanie Koenigshoff, MD, PhD
Professor of Medicine
University of Pittsburgh


Pharmacology & Chemical Biology Seminar Series
3/30/2023 - 12:00 PM-1:00 PM

Stefan Feske, MD 
Professor and Vice Chair for Research
Department of Pathology
Jeffrey Bergstein Professor of Medicine
New York University School of Medicine 


Pharmacology & Chemical Biology Seminar Series
4/6/2023 - 12:00 PM-1:00 PM

Steven Zheng, PhD 
University Professor
Department of Pharmacology
Rutgers-Robert Wood Johnson Medical School
Chief, Cancer Pharmacology and Co-Leader
Cancer Pharmacology Research Program
The Rutgers Cancer Institute of New Jersey


Pharmacology & Chemical Biology Seminar Series
4/13/2023 - 12:00 PM-1:00 PM

Gary Hammer, MD, PhD 
Millie Schembechler Professor of Adrenal Cancer
University of Michigan
Rogel Cancer Center


Pharmacology & Chemical Biology Seminar Series
4/20/2023 - 12:00 PM-1:00 PM

Allison Sharrow, PhD 
Research Assistant Professor
University of Pittsburgh


Pharmacology & Chemical Biology Seminar Series
4/27/2023 - 12:00 PM-1:00 PM

Stephen West, FRS, FMedSci 
Principal Group Leader
The Francis Crick Institute