Altschuler Lab


Daniel Altschuler, PhD
Associate Professor


Nyla Naim
Predoctoral Fellow


Xuefeng Zhang, PhD
Research Scientist

Daniel Altschuler, PhD

Zuo H, M Gandhi, MM Edreira, D Hochbaum, VL Nimgaonkar, P Zhang, J DiPaola, V Evdokimova, DL Altschuler and YE Nikiforov.  Downregulation of Rap1GAP through promoter hypermethylation and loss of heterozygosity promotes invasion and progression of thyroid tumors.  Cancer Research 70:1389-1397, 2010.
Edreira M, S Li, D Hochbaum, S Wong, AA Gorfe, F Ribeiro-Neto, VL Woods and DL Altschuler.  Phosphorylation-induced conformational changes in Rap1b:  Allosteric effects on switch domains and effector loop.  J Biol Chem 284:27480-27486, 2009.
Hochbaum D, K Hong, G Barila, F Ribeiro-Neto and DL Altschuler.  Epac, in synergy with PKA, is required for cAMP-mediated mitogenesis.  J Biol Chem 283:4464-4468, 2008.
Hong K, L Lou, S Gupta, F Ribeiro-Neto and DL Altschuler.  A novel Epac-Rap-PP2A signaling module controls cAMP-dependent Akt regulation.  J Biol Chem 283:23129-23138, 2008.
Ribeiro-Neto F, A Leon, J Urbani-Brocard, L Lou, A Nyska and DL Altschuler. cAMP-dependent oncogenic action of Rap1b in the thyroid gland. J Biol Chem 279:46868-4687, 2004.
Hochbaum D, T Tanos, F Ribeiro-Neto, DL Altschuler and OA Coso. Activation of JNK by Epac is independent of its activity as a Rap guanine nucleotide exchanger. J Biol Chem 278:33738-3374, 2003.
Lou L, J Urbani, F Ribeiro-Neto and DL Altschuler. cAMP inhibition of Akt is mediated by activated and phosphorylated Rap1b. J Biol Chem 277:32799-32806, 2002.
Ribeiro-Neto F, J Urbani, N Lemee, L Lou and DL Altschuler.  On the mitogenic properties of Rap1b:  cAMP-induced G(1)/S entry requires activated and phosphorylated Rap1b.  Proc Natl Acad Sci USA 99:5418-5423, 2002.

Nyla Naim

Peters S., Naim N., Nelson D., Mosier A.P., Cady N., Larsen M. Biocompatible tissue scaffold compliance promotes salivary gland morphogenesis and differentiation. Tissue Eng. 2014 Jun;20(11-12):1632-42 doi: 10.1089/ten.TEA.2013.0515.  PMID: 24410370 PMCID: PMC4029047