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University of Pittsburgh

Keri J. Fogle, PhD

Research Instructor

Education

B.S. (Biochemistry), Duquesne University, Pittsburgh, PA, 2000 M.A. (Neurobiology), Columbia University, New York, NY, 2003 Ph.D. (Neurobiology), Columbia University, New York, NY, 2007
Headshot of Keri J. Fogle, PhD
The ATP61 Drosophila model of mitochondrial encephalomyopathies shares common features with human diseases, including Maternally Inherited Leigh Syndrome (MILS) and Neuropathy, Ataxia, and Retinitis Pigmentosa (NARP). Some of the hallmarks of these diseases include neurodegeneration and seizure-like activity that is often unresponsive to commonly-used anti-epileptic drugs.
 
Dr. Fogle is using whole-cell patch clamp electrophysiology of the intact fly brain to explore the molecular mechanisms which underlie the neurobiological symptoms in the ATP61 model, specifically the membrane channel complexes which may couple metabolic disruption to neuronal dysfunction and hyperexcitability, and thus represent targets for novel therapeutic interventions.    

Journal Articles

Fogle KJ, KP Parson, NA Damn and TC Holmes.  Cryptochrome is a blue light sensor that modulates neuronal activity.  Science 331:1409-1413, 2011.
Sheeba V, KJ Vogle and TC  Holmes. Persistence of morning anticipation behavior and high amplitude morning startle response following functional loss of small ventral lateral neurons in Drosophila.  PLoS ONE 5:e11628, 2010.
Rozario AO, HK Turbendian, KJ Fogle, NB Olivier and GR Tibbs.  Voltage-dependent opening of HCN channels:  Facilitation by the phytoestrogen, genistein, is determined by the activation status of the cyclic nucleotide gating ring.  Biochim Biophys Acta 88:1939-1949, 2009.
Ayaz D, M Leyssen, M Koch, J Yan, M Srahna, V Sheeba, KJ Fogle, TC Holmes and BA Hassan.  Axonal injury and regeneration in the adult brain of Drosophila. J Neurosci 28:6010-6021, 2008.
Sheeba V, KJ Fogle, M Kaneko, S Rashid, YT Chou, VK Sharma and TC Holmes.  Large ventral lateral neurons modulate arousal and sleep in Drosophila.  Current Biology 18:1537-1545, 2008.
Fogle KJ, AK Lyaschenko, HK Turbendian and GR Gibbs.  HCN pacemaker channel activation is controlled by acidic lipids downstream of diacylglycerol kinase and phospholipase A2.  J Neurosci 27:2802-2814, 2007.