Elise Fouquerel, PhD

The Fouquerel laboratory is interested in deciphering the roles of DNA-dependent ADP Ribose Transferase enzymes PARPs in the repair of oxidative DNA damage and resolution of secondary DNA structures at telomeres and centromeres, two genomic regions whose integrity is crucial for overall genome stability. We utilize biochemical, molecular and cell biological tools to address our current questions. We also employ the FAP system, a highly innovative tool that allows for the local induction of oxidative DNA damage at the telomeres and the centromeres of mammalian cells. Our work contributes to improving the development of PARP inhibitors already largely used in cancer therapies and aims to provide new strategies for treating cancers and inform the rational design of PARP-targeted treatments.