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University of Pittsburgh

Lloyd Harvey

Predoctoral Fellow
BST 17th Floor, 200 Lothrop Street
Harvey.Lloyd@medstudent.pitt.edu

Education

University of Pittsburgh, BS, Neuroscience, 2015
Graduation
August 2021
Degree
MD/PhD
Where Are They Now?
Univ. of Pittsburgh School of Medicine-completing MD program

Research Summary

Molecular mechanisms of pulmonary hypertension

Headshot of Lloyd Harvey

Molecular mechanisms of pulmonary hypertension

Journal Articles

Acharya AP, Tang Y, Bertero T, Tai YY, Harvey LD, Woodcock CC, Sun W, Pineda R, Mitash N, Königshoff M, Little SR, Chan SY.   Simultaneous Pharmacologic Inhibition of Yes-Associated Protein 1 and Glutaminase 1 via Inhaled Poly(Lactic-co-Glycolic) Acid-Encapsulated Microparticles Improves Pulmonary Hypertension.J Am Heart Assoc. 2021 Jun 15;10(12):e019091. doi: 10.1161/JAHA.120.019091. Epub 2021 May 29. PMID: 34056915
 
Woodcock CC, Hafeez N, Handen A, Tang Y, Harvey LD, Estephan LE, Speyer G, Kim S, Bertero T, Chan SY.     Matrix stiffening induces a pathogenic QKI-miR-7-SRSF1 signaling axis in pulmonary arterial endothelial cells.Am J Physiol Lung Cell Mol Physiol. 2021 May 1;320(5):L726-L738. doi: 10.1152/ajplung.00407.2020. Epub 2021 Feb 10. PMID: 33565360   PMCID: PMC8174827
 
Harvey LD, Chan SY.   Evolving systems biology approaches to understanding non-coding RNAs in pulmonary hypertension.  J Physiol. 2019 Feb;597(4):1199-1208. doi: 10.1113/JP275855. Epub 2018 Sep 2. PMID: 30113078 PMCID: PMC6375871
Harvey LD, Chan SY.     YAPping About Glutaminolysis in Hepatic Fibrosis.Gastroenterology. 2018 Apr;154(5):1231-1233. doi: 10.1053/j.gastro.2018.03.007. Epub 2018 Mar 3. PMID: 29510133
PMCID: PMC6456336
 
Ranchoux B, Harvey LD, Ayon RJ, Babicheva A, Bonnet S, Chan SY, Yuan JX, Perez VJ.   Endothelial dysfunction in pulmonary arterial hypertension: an evolving landscape (2017 Grover Conference Series).  Pulm Circ. 2018 Jan-Mar;8(1):2045893217752912. doi: 10.1177/2045893217752912. Epub 2017 Dec 28. PMID: 29283043 PMCID: PMC5798691

 

Harvey LD, Chan SY. Emerging metabolic therapies in pulmonary arterial hypertension. J Clin Med. 2017;6(4). PubMed PMID: 28375184; PubMed Central PMCID: PMC5406775.

Harvey L, Yin Y, Attarwala IY, Begum G, Deng J, Yan HQ, Dixon CE, Sun D. Administration of DHA reduces ER stress-associated inflammation and alters microglial or macrophage activation in traumatic brain injury. ASN Neuro. 2015;7(6). PubMed PMID: 26685193; PubMed Central PMCID: PMC4710127.

Zonouzi M, Scafidi J, Li P, McEllin B, Edwards J, Dupree JL, Harvey L, Sun D, Hubner CA, Cull-Candy SG, Farrant M, Gallo V. GABAergic regulation of cerebellar NG2 cell development is altered in perinatal white matter injury. Nature Neuroscience. 2015;18(5):674-82. Epub 2015/03/31. doi: 10.1038/nn.3990. PubMed PMID: 25821912; PubMed Central PMCID: PMC4459267.

Begum G*, Harvey L*, Dixon CE, Sun D. ER stress and effects of DHA as an ER stress inhibitor. Translational Stroke Research. 2013;4(6):635-42. Epub 2013/12/11. doi: 10.1007/s12975-013-0282-1. PubMed PMID: 24323417; PubMed Central PMCID: PMC3864671. *denotes co-first authorship.

Awards and Honors

NIH F30 HL143879 HIV-infected Macrophages Induce Endothelial Cell Dysfunction and Metabolic Reprogramming to Promote HIV-associated Pulmonary Arterial Hypertension (2018-2021)

 
American Heart Association’s Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation (3CPR) Junior Investigator Travel Grant 2019
 

Sponsored Research

F30 HL143879