Jacob Lab


Matthew Bambino
Research Specialist II


Tija C. Jacob, PhD
Assistant Professor & Vice Chair for Graduate Education


Joshua Lorenz - Guertin
Predoctoral Fellow

Tija C. Jacob, PhD

Brady ML and TC Jacob.  Synaptic localization of alpha 5 GABA(A) receptors via gephyrin interaction regulates dendritic outgrowth and spine maturation.  Dev Neurobiol 75:1241-1251, 2015.
Brady ML, CE Moon and TC Jacob.  Using an alpha-bungarotoxin binding site tag to study GABA A receptor membrane localization and trafficking.  J Vis Exp 85:e51365, 2014
Petrini EM, T Ravasenga, TJ Hausrat, G Iurilli, U Olcese, V Racine, JC Sibarita, TC Jacob et al.  Synaptic recruitment of gephyrin regulates surface GABBA receptor dynamics for the expression of LTP.  Nat Commun 5:3921, 2014
Jacob TC, G Michels, L Silayeva, J Haydon, F Succol and SJ Moss.  Benzodiazepine treatment induces subtype-specific changes in GABAA receptor trafficking and decreases synaptic inhibition.  Proceedings of the National Academy of Sciences of the United States of America 109:18595-18600, 2012.
Jacob TC, Q Wan, M Vithlani, RS Saliba, F Succol, MN Pangalos and SJ Moss.  GABA(A) receptor membrane trafficking regulates spine maturity.  Proceedings of the National Academy of Sciences of the United States of America 106:12500-12505, 2009.
Jacob TC, SJ Moss and R Jurd.  GABA(A) receptor trafficking and its role in the dynamic modulation of neuronal inhibition.  Nature Reviews 9:331-343, 2008.
Tretter V, TC Jacob, J Mukherjee, JM Fritschy, MN Pangalos and SJ Moss.  The clustering of GABA(A) receptor subtypes at inhibitory synapses is facilitated via the direct binding of receptor alpha 2 subunits to gephyrin.  J Neurosci 28:1356-1365, 2008.
Saliba RS, G Michels, TC Jacob, MN Pangalos and SJ Moss.  Activity-dependent ubiquitination of GABA(A) receptors regulates their accumulation at synaptic sites.  J Neurosci 27:13341-13351, 2007.
Jacob TC.  RNAi and applications in neurobiology.  In:  The Dynamic Synapse:  Molecular Methods in Ionotropic Receptor Biology, JT Kittler, SJ Moss, editors.  Boca Raton, FL:  Taylor and Francis Group, LLC, 2006
Jacob TC*, YD Bogdanov*, C Magnus, RS Saliba, JT Kittler, PG Haydon and SJ Moss.  Gephyrin regulates the cell surface dynamics of synaptic GABAA receptors.  J Neurosci 25:10469-10478, 2005.  (*Authors contributed equally)
Jacob TC and JM Kaplan. The EGL-21 carboxypeptidase E facilitates acetylcholine release at Caenorhabditis elegans neuromuscular junctions. J Neurosci 23:2122-2130, 2003.
Kass J, TC Jacob, P Kim and JM Kaplan. The EGL-3 proprotein convertase regulates mechanosensory responses of Caenorhabditis elegans. J Neurosci 21:9265-9272, 2001.

Joshua Lorenz - Guertin

Joshua M. Lorenz-Guertin, Matthew J. Bambino and Tija C. Jacob* 2018, γ2 GABAAR Trafficking and the Consequences of Human Genetic Variation  Front. Cell. Neurosci., 23 August 2018 | https://doi.org/10.3389/fncel.2018.00265
Ye J, Das S, Roy A, Wei W, Huang H, Lorenz-Guertin JM, Zhang Z, Xu Q, Jacob TC, Wang B, Sun D, Wang QJ. Ischemic injury-induced CaMKIIδ and CaMKIIγ confer neuroprotection through the NF-κB signaling pathway. (June 2018 accepted in Mol Neurobiol).
Brady ML, Pilli J, Lorenz-Guertin JM, Das S, Moon CE, Graff N, Jacob TC. 2018, Depolarizing, inhibitory GABA type A receptor activity regulates GABAergic synapse plasticity via ERK and BDNF signaling. Neuropharmacology. 2018 Jan;128:324-339. doi: 10.1016/j.neuropharm.2017.10.022. Epub 2017 Oct 23. PMID: 29074304 PMCID: PMC5739058
Lorenz-Guertin JM, Wilcox MR, Zhang M, Larsen MB, Pilli J, Schmidt BF, Bruchez MP, Johnson JW, Waggoner AS, Watkins SC, Jacob TC. 2017,  A versatile optical tool for studying synaptic GABAA receptor trafficking. J Cell Sci. 2017 Nov 15;130(22):3933-3945. doi: 10.1242/jcs.205286. Epub 2017 Oct 12. PMID:     29025969 PMCID: PMC5702044
Lorenz-Guertin JM, Jacob TC.  2018, GABA type a receptor trafficking and the architecture of synaptic inhibition. Dev Neurobiol. 2018 Mar;78(3):238-270. doi: 10.1002/dneu.22536. Epub 2017 Sep 19. Review. PMID 28901728