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"Role of the Tumor Suppressor BRCA2 in Chromosome ...
Pharmacology & Chemical Biology Seminar Series
3/11/2021 - 12:00 PM-1:00 PM
"Role of the Tumor Suppressor BRCA2 in Chromosome Damage Repair"
Patrick M. Sung, Ph.D.
Professor of Biochemistry & Structural Biology
Robert A. Welch Distinguished Chair in Biohemistry
The University of Texas Health Science Center at San Antonio
Abstract:
BRCA2 is one of several breast tumor suppressors that play crucial roles in DNA damage repair by homologous recombination, a process in which a homologous, undamaged chromatid serves as the information donor in the error-free removal of DNA double-strand breaks and other deleterious chromosomal lesions, such as collapsed DNA replication forks. BRCA2 encodes an exceptionally large protein (≥400 kDa) that harbors functional domains for interactions with DNA and with other DNA repair proteins. Using in vitro reconstitution with highly purified BRCA2 species and companion cell-based and biophysical analyses, our studies have furnished mechanistic insights into the complex DNA damage repair role of BRCA2. Highlights of these studies and their implications will be discussed.
Contact
Melanie Hoffner
412/383-7757