Office:	1704.2 BST
	200 Lothrop St
	Pittsburgh, PA 15216
Phone:	412-383-6030
Fax:
E-mail:	chansy@upmc.edu

Education
	PhD, University of California, San Francisco, CA, 2001
	MD, University of California, San Francisco, CA, 2003

Training
	Residency, Internal Medicine, Brigham and Women's Hospital, Boston, MA, 2005
	Clinical and Research Fellowship in Cardiology, Massachusetts General Hospital, Boston, MA, 2009
	Research Fellow in Medicine, Harvard Medical School, Boston, MA, 2009

I lead a basic science and translational research group studying the molecular mechanisms of pulmonary vascular disease and pulmonary hypertension (PH) – an example of an enigmatic disease where reductionistic studies have primarily focused on end-stage molecular effectors. To capitalize on the emerging discipline of "network medicine," our research utilizes a combination of network-based bioinformatics with unique experimental reagents derived from genetically altered rodent and human subjects to accelerate systems-wide discovery in PH. Our published findings were among the first to identify the systems-level functions of microRNAs (miRNAs), which are small, non-coding RNAs that negatively regulate gene expression, as a root cause of PH. Our lab developed novel in silico approaches to analyze gene network architecture coupled with in vivo experimentation. The results now offer methods to identify persons at-risk for PH and develop therapeutic RNA targets. This work is the cornerstone of our evolving applications of network theory to the discovery of RNA-based origins of human diseases, in general.

I serve as Director for the Center for Pulmonary Vascular Biology and Medicine, a multidisciplinary clinical and research center devoted to the care of patients afflicted with pulmonary vascular diseases. I have an outpatient clinic where I specialize in the care of patients with pulmonary hypertension. I also serve as an attending physician on the inpatient general cardiology service.

I am invested in educating both scientists and physicians in cardiovascular and pulmonary vascular medicine. I have served as the primary research mentor for 11 trainees over the past 4 years, including 6 postdoctoral fellows, 1 doctoral student, and 4 undergraduate students. Of my post-doctoral trainees, two post-doctoral fellows have since started independent academic laboratories as PI’s, two have transitioned to principal scientist positions in industry, and two are current fellows in my lab. The doctoral student is currently a cardiology fellow at Stanford pursuing an academic research career. Of the undergraduate students, one has matriculated to the UPenn MSTP and another has matriculated in a Ph.D. program in biology at the University of North Carolina. I serve as Associate Fellowship Director in Cardiology where I direct the research program for our fellows. I also enjoy teaching both graduate and post-graduate trainees on the inpatient cardiology service and in didactic settings.

For my complete bibliography, Click Here.

Selected Publications: