Jiang Lab

The Jiang lab is interested in the signaling mechanism by which Tor mediates cell growth and proliferation. Tor, a homologue of ATM and the DNA dependent kinase, is a key regulator of cell growth and proliferation in most eukaryotic cells. It is also the target of the immunosuppressive drug rapamycin, which exerts its anti-inflammatory effect by specifically inhibiting Tor function in lymphoid cells. Tor controls many diverse cellular processes in response to both nutrient and growth factor signals. Emerging evidence suggests that Tor acts as a checkpoint protein to impinge nutrient signals into growth factor mediated processes. In this view, Tor activity ensures that cell growth occurs only when the nutrient requirement is met. The lab has been using yeast Saccharomyces cerevisiae as a model system to study Tor mediated signaling pathway. Recent studies in his laboratory have established protein phosphatase 2A as a major downstream target of the Tor signaling. His laboratory is currently investigating how Tor mediates PP2A activity and how PP2A relays Tor signaling activity to many cellular processes.

Yu Jiang, PhD
Associate Professor

Jingmei Li
Visiting Student

Liping Wang
Visiting Scientist

Mingming Zhong
Visiting Student

Yichao Zhu
Visiting Scientist

Yu Jiang, PhD

Wang J, D Saralin, S Menon, J Zhang, J Ding, S Cervantes, E Miller, Y Jiang and S Ferro-Novick. Ypt1/Rab1 regulates ER-Golgi traffic and autophagosome formation by a common mechanism. J Cell Biol 210:273-285, 2015.
Zou H, Yi Lai, D Ma, N Cardenes, S Shiva, Y Liu, X Bai, Y Jiang and Y Jiang. Regulation of the mammalian target of rapamycin complex 1 by anti-apoptotic proteins Bcl-2 and Bcl-XL. J Biol Chem 288:28824-28830, 2013.
Wang J, S Menon, A Yamasaki, HT Chou, T Walz, Y Jiang and S Ferro-Novick. Ypt1 recruits the Atg1 kinase to the preautophagosomal structure. Proc Natl Acad Sci USA 110:9800-9805, 2013.
Yan G, Y Lai and Y Jiang.  TORC1 is a direct target of Rho1 GTPase. Molecular Cell 45:743-753, 2012.
Ma D, X Bai, H Zou and Y Jiang.  Rheb GTPase controls apoptosis by regulating interaction of FKBP38 with Bcl-2 and Bcl-XL. J Biol Chem  285:8621-8627, 2010.
Guo S, X Shen, G Yan, D Ma, X Bai, S Li, and Y Jiang.  A MAP kinase dependent feedback mechanism controls Rho1 GTPase and actin distribution in yeast. PLoS One 4(6):e6089, 2009.
Bai X, D Ma, A Liu, X Shen, QJ Wang, Y Liu and Y Jiang.  Rheb activitates mTOR by antagonizing its endogenous inhibitor, FKBP38.  Science 318:977-980, 2007.